Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

David Croteau; Brookie M. Best; Scott Letendre; Steven S. Rossi; Ronald J. Ellis; David B. Clifford; Ann C. Collier; Benjamin B. Gelman; Justin C. McArthur; John Allen McCutchan; Susan Morgello; Igor Grant

doi:10.1097/QAD.0b013e328351f627

Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

David Croteau, Brookie M. Best, Scott Letendre, Steven S. Rossi, Ronald J. Ellis, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Justin C. McArthur, John Allen McCutchan, Susan Morgello, Igor Grant

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.

Original language	English (US)
Pages (from-to)	890-893
Number of pages	4
Journal	AIDS
Volume	26
Issue number	7
DOIs	https://doi.org/10.1097/QAD.0b013e328351f627
State	Published - Apr 24 2012

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Croteau, D., Best, B. M., Letendre, S., Rossi, S. S., Ellis, R. J., Clifford, D. B., Collier, A. C., Gelman, B. B., McArthur, J. C., McCutchan, J. A., Morgello, S., & Grant, I. (2012). Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. AIDS, 26(7), 890-893. https://doi.org/10.1097/QAD.0b013e328351f627

Croteau, D, Best, BM, Letendre, S, Rossi, SS, Ellis, RJ, Clifford, DB, Collier, AC, Gelman, BB, McArthur, JC, McCutchan, JA, Morgello, S & Grant, I 2012, 'Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration', AIDS, vol. 26, no. 7, pp. 890-893. https://doi.org/10.1097/QAD.0b013e328351f627

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title = "Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration",

abstract = "To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.",

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AU - Croteau, David

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AU - Letendre, Scott

AU - Rossi, Steven S.

AU - Ellis, Ronald J.

AU - Clifford, David B.

AU - Collier, Ann C.

AU - Gelman, Benjamin B.

AU - McArthur, Justin C.

AU - McCutchan, John Allen

AU - Morgello, Susan

AU - Grant, Igor

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AB - To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.

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Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

Abstract

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