Abstract
Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes.Methods. A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool.Results. Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was associated with both lower adherence rates (P =. 004) and worse virological suppression (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1297-1307 |
| Number of pages | 11 |
| Journal | Clinical Infectious Diseases |
| Volume | 58 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- ART
- fixed-dose combination
- once-daily
- randomized controlled trials
- twice-daily
ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
- Medicine(all)
Cite this
Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection : A meta-analysis of randomized controlled trials. / Nachega, Jean B.; Parienti, Jean Jacques; Uthman, Olalekan A.; Gross, Robert; Dowdy, David Wesley; Sax, Paul E.; Gallant, Joel E.; Mugavero, Michael J.; Mills, Edward J.; Giordano, Thomas P.
In: Clinical Infectious Diseases, Vol. 58, No. 9, 2014, p. 1297-1307.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection
T2 - A meta-analysis of randomized controlled trials
AU - Nachega, Jean B.
AU - Parienti, Jean Jacques
AU - Uthman, Olalekan A.
AU - Gross, Robert
AU - Dowdy, David Wesley
AU - Sax, Paul E.
AU - Gallant, Joel E.
AU - Mugavero, Michael J.
AU - Mills, Edward J.
AU - Giordano, Thomas P.
PY - 2014
Y1 - 2014
N2 - Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes.Methods. A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool.Results. Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was associated with both lower adherence rates (P =. 004) and worse virological suppression (P
AB - Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes.Methods. A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool.Results. Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was associated with both lower adherence rates (P =. 004) and worse virological suppression (P
KW - ART
KW - fixed-dose combination
KW - once-daily
KW - randomized controlled trials
KW - twice-daily
UR - http://www.scopus.com/inward/record.url?scp=84898050780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898050780&partnerID=8YFLogxK
U2 - 10.1093/cid/ciu046
DO - 10.1093/cid/ciu046
M3 - Article
C2 - 24457345
AN - SCOPUS:84898050780
VL - 58
SP - 1297
EP - 1307
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -