Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials

Jean B. Nachega, Jean Jacques Parienti, Olalekan A. Uthman, Robert Gross, David Wesley Dowdy, Paul E. Sax, Joel E. Gallant, Michael J. Mugavero, Edward J. Mills, Thomas P. Giordano

Research output: Contribution to journalArticle

Abstract

Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes.Methods. A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool.Results. Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was associated with both lower adherence rates (P =. 004) and worse virological suppression (P

Original languageEnglish (US)
Pages (from-to)1297-1307
Number of pages11
JournalClinical Infectious Diseases
Volume58
Issue number9
DOIs
StatePublished - 2014

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HIV Infections
Meta-Analysis
Randomized Controlled Trials
Outcome Assessment (Health Care)
Population Characteristics
Databases
Therapeutics

Keywords

  • ART
  • fixed-dose combination
  • once-daily
  • randomized controlled trials
  • twice-daily

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

Cite this

Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection : A meta-analysis of randomized controlled trials. / Nachega, Jean B.; Parienti, Jean Jacques; Uthman, Olalekan A.; Gross, Robert; Dowdy, David Wesley; Sax, Paul E.; Gallant, Joel E.; Mugavero, Michael J.; Mills, Edward J.; Giordano, Thomas P.

In: Clinical Infectious Diseases, Vol. 58, No. 9, 2014, p. 1297-1307.

Research output: Contribution to journalArticle

Nachega, JB, Parienti, JJ, Uthman, OA, Gross, R, Dowdy, DW, Sax, PE, Gallant, JE, Mugavero, MJ, Mills, EJ & Giordano, TP 2014, 'Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials', Clinical Infectious Diseases, vol. 58, no. 9, pp. 1297-1307. https://doi.org/10.1093/cid/ciu046
Nachega, Jean B. ; Parienti, Jean Jacques ; Uthman, Olalekan A. ; Gross, Robert ; Dowdy, David Wesley ; Sax, Paul E. ; Gallant, Joel E. ; Mugavero, Michael J. ; Mills, Edward J. ; Giordano, Thomas P. / Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection : A meta-analysis of randomized controlled trials. In: Clinical Infectious Diseases. 2014 ; Vol. 58, No. 9. pp. 1297-1307.
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