Lower myocardial perfusion reserve is associated with decreased regional left ventricular function in asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis

Boaz D. Rosen, Joao Lima, Khurram Nasir, Thor Edvardsen, Aaron R. Folsom, Shenghan Lai, David A. Bluemke, Michael Jerosch-Herold

Research output: Contribution to journalArticle

Abstract

BACKGROUND - Myocardial ischemia is an important determinant of regional left ventricular systolic function. Myocardial blood flow reserve may be impaired by cardiovascular disease before alterations of myocardial perfusion at rest become manifest. Nevertheless, the relation between flow reserve and regional myocardial function has not been studied in individuals without a history of clinical heart disease. METHODS AND RESULTS - Seventy-four participants (66±9 years, mean±SD) of the Multi-Ethnic Study of Atherosclerosis (MESA) underwent myocardial magnetic resonance tagging and contrast-enhanced perfusion studies. Regional myocardial function was evaluated as peak systolic circumferential strain (Ecc) in the three main coronary territories (left anterior descending [LAD], left circumflex, and right coronary artery [RCA]). Myocardial blood flow at rest and during adenosine-induced hyperemia was quantified by contrast-enhanced magnetic resonance imaging, to study the relation between regional flow and function after multivariable adjustment for age, gender, body mass index, left ventricular mass, and traditional risk factors. Lower regional myocardial blood flow during hyperemia was associated with reduced regional left ventricular function expressed as lower Ecc in the RCA (P

Original languageEnglish (US)
Pages (from-to)289-297
Number of pages9
JournalCirculation
Volume114
Issue number4
DOIs
StatePublished - Jul 2006

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Hyperemia
Left Ventricular Function
Atherosclerosis
Coronary Vessels
Perfusion
Regional Blood Flow
Adenosine
Myocardial Ischemia
Heart Diseases
Body Mass Index
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • Contractility
  • Epidemiology
  • Magnetic resonance imaging
  • Myocardium
  • Regional blood flow
  • Risk factors
  • Systole

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lower myocardial perfusion reserve is associated with decreased regional left ventricular function in asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis. / Rosen, Boaz D.; Lima, Joao; Nasir, Khurram; Edvardsen, Thor; Folsom, Aaron R.; Lai, Shenghan; Bluemke, David A.; Jerosch-Herold, Michael.

In: Circulation, Vol. 114, No. 4, 07.2006, p. 289-297.

Research output: Contribution to journalArticle

Rosen, Boaz D. ; Lima, Joao ; Nasir, Khurram ; Edvardsen, Thor ; Folsom, Aaron R. ; Lai, Shenghan ; Bluemke, David A. ; Jerosch-Herold, Michael. / Lower myocardial perfusion reserve is associated with decreased regional left ventricular function in asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis. In: Circulation. 2006 ; Vol. 114, No. 4. pp. 289-297.
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AU - Edvardsen, Thor

AU - Folsom, Aaron R.

AU - Lai, Shenghan

AU - Bluemke, David A.

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N2 - BACKGROUND - Myocardial ischemia is an important determinant of regional left ventricular systolic function. Myocardial blood flow reserve may be impaired by cardiovascular disease before alterations of myocardial perfusion at rest become manifest. Nevertheless, the relation between flow reserve and regional myocardial function has not been studied in individuals without a history of clinical heart disease. METHODS AND RESULTS - Seventy-four participants (66±9 years, mean±SD) of the Multi-Ethnic Study of Atherosclerosis (MESA) underwent myocardial magnetic resonance tagging and contrast-enhanced perfusion studies. Regional myocardial function was evaluated as peak systolic circumferential strain (Ecc) in the three main coronary territories (left anterior descending [LAD], left circumflex, and right coronary artery [RCA]). Myocardial blood flow at rest and during adenosine-induced hyperemia was quantified by contrast-enhanced magnetic resonance imaging, to study the relation between regional flow and function after multivariable adjustment for age, gender, body mass index, left ventricular mass, and traditional risk factors. Lower regional myocardial blood flow during hyperemia was associated with reduced regional left ventricular function expressed as lower Ecc in the RCA (P

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