Low Vitamin D is associated with coronary atherosclerosis in women with HIV

Lediya T. Cheru, Charles F. Saylor, Kathleen V. Fitch, Sara E. Looby, Michael Lu, Udo Hoffmann, Takara L. Stanley, Janet Lo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Vitamin D deficiency is underdiagnosed and undertreated, especially among people living with HIV (PLWH). Recently, there has been an increased interest in the role of Vitamin D in cardiovascular disease (CVD). While Vitamin D deficiency has been associated with CVD in observational studies in the general population, there are limited data in PLWH. We therefore performed an analysis to assess the relationship of Vitamin D and coronary athAêrosclerosis using coronary CT angiography (CCTA). Methods: Women living with HIV (WLWH) without known CVD were included. Based on the median value of serum Vitamin D levels, participants were dichoto-mized to either the <25 ng/ml (lower Vitamin D group) or >25 ng/ml (higher Vitamin D group). CCTA was used to assess plaque characteristics. Results: Forty-three WLWH were included in the analyses (mean age 46 ±8 years, 56% African American, duration of HIV 15 ±6 years, 83% undetectable HIV viral load). WLWH in the lower Vitamin D group (/;=22) had significantly higher numbers of segments with any coronary plaque (2.27 ±3.01 versus 0.38 ±0.97; P=0.02) and segments with non-calcified coronary plaque (1.41 ±1.82 versus 0.29 ±0.64; P=0.03) comÂpared with WLWH in the higher Vitamin D group (/;=21). After adjusting for Framingham CHD risk point score, body mass index, diabetes and race, the relation-ship remained significant. Conclusions: Our study demonstrates a significant, indeÂpendent relationship between lower Vitamin D status and higher numbers of noncalcified coronary plaque segments in WLWH. Further studies are warranted to evaluate the effect of Vitamin D on CVD in PLWH. Trial Registration Identifier: NCT00455793.

Original languageEnglish (US)
Pages (from-to)505-512
Number of pages8
JournalAntiviral therapy
Volume24
Issue number7
DOIs
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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