Low testosterone levels and the risk of anemia in older men and women

Luigi Ferrucci, Marcello Maggio, Stefania Bandinelli, Shehzad Basaria, Fulvio Lauretani, Alessandro Ble, Giorgio Valenti, William B. Ershler, Jack M. Guralnik, Dan L. Longo

Research output: Contribution to journalArticle


Background: Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia. Methods: Testosterone and hemoglobin levels were measured in a representative sample of 905 persons 65 years or older without cancer, renal insufficiency, or antiandrogenic treatments. Hemoglobin levels were reassessed after 3 years. Results: At baseline, 31 men and 57 women had anemia. Adjusting for confounders, we found that total and bioavailable testosterone levels were associated with hemoglobin levels in women (P=.001 and P=.02, respectively) and in men (P

Original languageEnglish (US)
Pages (from-to)1380-1388
Number of pages9
JournalArchives of Internal Medicine
Issue number13
StatePublished - Jul 10 2006
Externally publishedYes


ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ferrucci, L., Maggio, M., Bandinelli, S., Basaria, S., Lauretani, F., Ble, A., Valenti, G., Ershler, W. B., Guralnik, J. M., & Longo, D. L. (2006). Low testosterone levels and the risk of anemia in older men and women. Archives of Internal Medicine, 166(13), 1380-1388. https://doi.org/10.1001/archinte.166.13.1380