Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: A prospective study

Katie L. Stone, Douglas C. Bauer, Deborah Sellmeyer, Steven R. Cummings

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to test whether low serum vitamin B-12 levels are associated with more rapid bone loss in elderly women. We archived sera and measured calcaneal bone mineral density (BMD) in community-dwelling white women, aged 65 yr and over, who participated in the Study of Osteoporotic Fractures. BMD of the hip and subregions was measured 2 yr later. Repeat measurements of calcaneal and hip BMD were obtained after 5.9 and 3.5 yr of follow-up, respectively. Serum vitamin B-12 assays were performed in 83 randomly selected participants with initial and repeat measurements of BMD who were not taking estrogen replacement therapy at baseline. After adjusting for age, weight, and clinic site, women with vitamin B-12 levels at or below 280 pg/ml (207.2 pmol/liter; lowest quintile) experienced an annual change of -1.6% (95% confidence interval, -2.4% to -0.8%) in total hip BMD, compared with -0.2% (-0.5% to 0.2%) in women with levels above 280 pg/ml (P = 0.003). Results were similar when subregions of the hip were analyzed separately. Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Pelvic Bones
Vitamin B 12
Bone Density
Bone
Prospective Studies
Minerals
Hip
Serum
Bone and Bones
Independent Living
Osteoporotic Fractures
Estrogen Replacement Therapy
Confidence Intervals
Weights and Measures
Assays
Estrogens

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Low serum vitamin B-12 levels are associated with increased hip bone loss in older women : A prospective study. / Stone, Katie L.; Bauer, Douglas C.; Sellmeyer, Deborah; Cummings, Steven R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 3, 03.2004, p. 1217-1221.

Research output: Contribution to journalArticle

Stone, Katie L. ; Bauer, Douglas C. ; Sellmeyer, Deborah ; Cummings, Steven R. / Low serum vitamin B-12 levels are associated with increased hip bone loss in older women : A prospective study. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 3. pp. 1217-1221.
@article{99e9921984bc4c7797c4c175dda9e982,
title = "Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: A prospective study",
abstract = "The purpose of this study was to test whether low serum vitamin B-12 levels are associated with more rapid bone loss in elderly women. We archived sera and measured calcaneal bone mineral density (BMD) in community-dwelling white women, aged 65 yr and over, who participated in the Study of Osteoporotic Fractures. BMD of the hip and subregions was measured 2 yr later. Repeat measurements of calcaneal and hip BMD were obtained after 5.9 and 3.5 yr of follow-up, respectively. Serum vitamin B-12 assays were performed in 83 randomly selected participants with initial and repeat measurements of BMD who were not taking estrogen replacement therapy at baseline. After adjusting for age, weight, and clinic site, women with vitamin B-12 levels at or below 280 pg/ml (207.2 pmol/liter; lowest quintile) experienced an annual change of -1.6{\%} (95{\%} confidence interval, -2.4{\%} to -0.8{\%}) in total hip BMD, compared with -0.2{\%} (-0.5{\%} to 0.2{\%}) in women with levels above 280 pg/ml (P = 0.003). Results were similar when subregions of the hip were analyzed separately. Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women.",
author = "Stone, {Katie L.} and Bauer, {Douglas C.} and Deborah Sellmeyer and Cummings, {Steven R.}",
year = "2004",
month = "3",
doi = "10.1210/jc.2003-030074",
language = "English (US)",
volume = "89",
pages = "1217--1221",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Low serum vitamin B-12 levels are associated with increased hip bone loss in older women

T2 - A prospective study

AU - Stone, Katie L.

AU - Bauer, Douglas C.

AU - Sellmeyer, Deborah

AU - Cummings, Steven R.

PY - 2004/3

Y1 - 2004/3

N2 - The purpose of this study was to test whether low serum vitamin B-12 levels are associated with more rapid bone loss in elderly women. We archived sera and measured calcaneal bone mineral density (BMD) in community-dwelling white women, aged 65 yr and over, who participated in the Study of Osteoporotic Fractures. BMD of the hip and subregions was measured 2 yr later. Repeat measurements of calcaneal and hip BMD were obtained after 5.9 and 3.5 yr of follow-up, respectively. Serum vitamin B-12 assays were performed in 83 randomly selected participants with initial and repeat measurements of BMD who were not taking estrogen replacement therapy at baseline. After adjusting for age, weight, and clinic site, women with vitamin B-12 levels at or below 280 pg/ml (207.2 pmol/liter; lowest quintile) experienced an annual change of -1.6% (95% confidence interval, -2.4% to -0.8%) in total hip BMD, compared with -0.2% (-0.5% to 0.2%) in women with levels above 280 pg/ml (P = 0.003). Results were similar when subregions of the hip were analyzed separately. Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women.

AB - The purpose of this study was to test whether low serum vitamin B-12 levels are associated with more rapid bone loss in elderly women. We archived sera and measured calcaneal bone mineral density (BMD) in community-dwelling white women, aged 65 yr and over, who participated in the Study of Osteoporotic Fractures. BMD of the hip and subregions was measured 2 yr later. Repeat measurements of calcaneal and hip BMD were obtained after 5.9 and 3.5 yr of follow-up, respectively. Serum vitamin B-12 assays were performed in 83 randomly selected participants with initial and repeat measurements of BMD who were not taking estrogen replacement therapy at baseline. After adjusting for age, weight, and clinic site, women with vitamin B-12 levels at or below 280 pg/ml (207.2 pmol/liter; lowest quintile) experienced an annual change of -1.6% (95% confidence interval, -2.4% to -0.8%) in total hip BMD, compared with -0.2% (-0.5% to 0.2%) in women with levels above 280 pg/ml (P = 0.003). Results were similar when subregions of the hip were analyzed separately. Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women.

UR - http://www.scopus.com/inward/record.url?scp=1642399817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642399817&partnerID=8YFLogxK

U2 - 10.1210/jc.2003-030074

DO - 10.1210/jc.2003-030074

M3 - Article

C2 - 15001613

AN - SCOPUS:1642399817

VL - 89

SP - 1217

EP - 1221

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -