TY - JOUR
T1 - Low serum selenium is associated with anemia among older adults in the United States
AU - Semba, R. D.
AU - Ricks, M. O.
AU - Ferrucci, L.
AU - Xue, Q. L.
AU - Guralnik, J. M.
AU - Fried, L. P.
N1 - Funding Information:
This study was sponsored by National Institute on Aging, National Institutes of Health (R01 AG027012, R01 AG029148 and Intramural Research Branch).
PY - 2009
Y1 - 2009
N2 - Objective: We hypothesized that low serum selenium was associated with anemia in humans.Subjects:A total of 2092 adults aged 65 and older, in the third National Nutrition Examination Survey, Phase 2 (1991-1994) (NHANES III). Methods: Examination of the relationship between serum selenium and hematological indices in NHANES III. Results: Anemia, defined by World Health Organization criteria, was present in 12.9%. Mean serum selenium among non-anemic and anemic adults was 1.60 and 1.51 μmol l-1 (P = 0.0003). The prevalence of anemia among adults in the lowest to highest quartiles of serum selenium was 18.3, 9.5, 9.7 and 6.9%, respectively (P = 0.0005). The proportion of adults in the lowest quartile of selenium among those who were non-anemic or who had anemia due to nutritional causes, chronic inflammation, renal disease or unexplained anemia was 9.9, 27.5, 17.5, 24.0 and 15.4%, respectively. An increase in loge selenium was associated with a reduced risk of anemia (odds ratio per one standard deviation increase 0.75, 95% confidence interval 0.58-0.97, P = 0.03), adjusting for age, race, education, body mass index and chronic diseases. Conclusion: Low serum selenium is independently associated with anemia among older men and women in the United States.
AB - Objective: We hypothesized that low serum selenium was associated with anemia in humans.Subjects:A total of 2092 adults aged 65 and older, in the third National Nutrition Examination Survey, Phase 2 (1991-1994) (NHANES III). Methods: Examination of the relationship between serum selenium and hematological indices in NHANES III. Results: Anemia, defined by World Health Organization criteria, was present in 12.9%. Mean serum selenium among non-anemic and anemic adults was 1.60 and 1.51 μmol l-1 (P = 0.0003). The prevalence of anemia among adults in the lowest to highest quartiles of serum selenium was 18.3, 9.5, 9.7 and 6.9%, respectively (P = 0.0005). The proportion of adults in the lowest quartile of selenium among those who were non-anemic or who had anemia due to nutritional causes, chronic inflammation, renal disease or unexplained anemia was 9.9, 27.5, 17.5, 24.0 and 15.4%, respectively. An increase in loge selenium was associated with a reduced risk of anemia (odds ratio per one standard deviation increase 0.75, 95% confidence interval 0.58-0.97, P = 0.03), adjusting for age, race, education, body mass index and chronic diseases. Conclusion: Low serum selenium is independently associated with anemia among older men and women in the United States.
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U2 - 10.1038/sj.ejcn.1602889
DO - 10.1038/sj.ejcn.1602889
M3 - Article
C2 - 17805227
AN - SCOPUS:58149477875
SN - 0954-3007
VL - 63
SP - 93
EP - 99
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 1
ER -