Low serum selenium and total carotenoids predict mortality among older women living in the community: The Women's Health and Aging Studies

Amanda L. Ray, Richard D. Semba, Jeremy Walston, Luigi Ferrucci, Anne R. Cappola, Michelle O. Ricks, Qian Li Xue, Linda P. Fried

Research output: Contribution to journalArticlepeer-review

Abstract

Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and II in Baltimore, MD (n = 632; 70-79 y old) had serum selenium and carotenoids measured at baseline and were followed for mortality over 60 mo. Median (minimum, maximum) serum selenium and carotenoids were 1.53 (0.73, 2.51) μmol/L and 1.67 (0.13, 9.10) μmol/L; 14.1% of the women died. The 5 major causes of death were heart disease (32.6%), cancer (18.0%), stroke (9.0%), infection (6.7%), and chronic obstructive pulmonary disease (5.6%). Adjusting for age, education, smoking, BMI, poor appetite, and chronic diseases, higher serum selenium [hazard ratio (HR) 0.71, 95% CI 0.56-0.90/1 SD increase in loge selenium; P = 0.005] and higher serum total carotenoids (HR 0.77, 95% CI 0.64-0.84/1 SD increase in loge total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalJournal of Nutrition
Volume136
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Aging
  • Carotenoids
  • Mortality
  • Selenium
  • Women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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