Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy

Amita Gupta, Nikhil Gupte, Ramesh Bhosale, Arjun Kakrani, Vandana Kulkarni, Uma Nayak, Madhuri Thakar, Jayagowri Sastry, Robert C Bollinger

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults. In light of expanding ART access through prevention of mother-to-child transmission (PMTCT)-plus programs in resource-limited settings, we assessed the sensitivity, specificity, and positive predictive value (PPV) of TLC for predicting low CD4 counts in antepartum and postpartum women in Pune, India. METHODS: CD4, TLC, and hemoglobin were measured at third trimester, delivery, and 6, 9, and 12 months postpartum (PP) in a cohort of 779 HIV-infected women. Optimal TLC cutoff for predicting CD4

Original languageEnglish (US)
Pages (from-to)338-342
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume46
Issue number3
DOIs
StatePublished - Nov 2007

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Lymphocyte Count
Postpartum Period
CD4 Lymphocyte Count
Biomarkers
Third Pregnancy Trimester
Therapeutics
India
Hemoglobins
Mothers
HIV
Sensitivity and Specificity

Keywords

  • CD4
  • India
  • Positive predictive value
  • Total lymphocyte count
  • Women

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy. / Gupta, Amita; Gupte, Nikhil; Bhosale, Ramesh; Kakrani, Arjun; Kulkarni, Vandana; Nayak, Uma; Thakar, Madhuri; Sastry, Jayagowri; Bollinger, Robert C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 46, No. 3, 11.2007, p. 338-342.

Research output: Contribution to journalArticle

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