Low residual CBF variability in Alzheimer's disease after correction for CO 2 effect

Anders Bertil Rodell, Joel Aanerud, Hans Braendgaard, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

We tested the claim that inter-individual CBF variability in Alzheimer's disease (AD) is substantially reduced after correction for arterial carbon dioxide tension (PaCO 2). Specifically, we tested whether the variability of CBF in brain of patients with AD differed significantly from brain of age-matched healthy control subjects (HC).To eliminate the CO 2-induced variability, we developed a novel and generally applicable approach to the correction of CBF for changes of PaCO 2 and applied the method to positron emission tomographic (PET) measures of CBF in AD and HC groups of subjects. After correction for the differences of CO 2 tension, the patients with AD lost the inter-individual CBF variability that continued to characterize the HC subjects. The difference (ΔK 1) between the blood-brain clearances (K 1) of water (the current measure of CBF) and oxygen (the current measure of oxygen clearance) was reduced globally in AD and particularly in the parietal, occipital, and temporal lobes. We then showed that oxygen gradients calculated for brain tissue were similar in AD and HC, indicating that the low residual variability of CBF in AD may be due to low functional demands for oxidative metabolism of brain tissue rather than impaired delivery of oxygen.

Original languageEnglish (US)
Article number8
JournalFrontiers in Neuroenergetics
Issue numberJULY
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Carbon Monoxide
Alzheimer Disease
Healthy Volunteers
Oxygen
Brain
Occipital Lobe
Parietal Lobe
Temporal Lobe
Carbon Dioxide
Electrons
Control Groups
Water

Keywords

  • Alzheimer's disease
  • Brain energy metabolism
  • Cerebral blood flow
  • Cerebral metabolic rate for oxygen
  • Cerebral vasoreactivity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Low residual CBF variability in Alzheimer's disease after correction for CO 2 effect. / Rodell, Anders Bertil; Aanerud, Joel; Braendgaard, Hans; Gjedde, Albert.

In: Frontiers in Neuroenergetics, No. JULY, 8, 2012.

Research output: Contribution to journalArticle

Rodell, Anders Bertil ; Aanerud, Joel ; Braendgaard, Hans ; Gjedde, Albert. / Low residual CBF variability in Alzheimer's disease after correction for CO 2 effect. In: Frontiers in Neuroenergetics. 2012 ; No. JULY.
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