Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation?

S. K. Shankar, P. Satishchandra, A. Mahadevan, T. C. Yasha, D. Nagaraja, A. B. Taly, S. Prabhakar, A. Nath

Research output: Contribution to journalArticle

Abstract

Infection with human immunodeficiency virus (HIV) clade C virus is the most common form of HIV infection in the world. It largely infects populations in Africa and Asia and not much is known about the neurological complications associated with the virus. Cases of progressive multifocal leukoencephalopathy (PML) have been rarely reported in the literature in the acquired immunodeficiency syndrome (AIDS) or non-AIDS populations from these regions. In this article, the authors present three recently diagnosed patients with AIDS and PML from one neurological center in India, review the diagnostic challenges faced, and speculate on the possible biological-reasons, including viral strain differences as well as HIV and JC virus interactions, that may account for the low incidence.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalJournal of NeuroVirology
Volume9
Issue numberSUPPL. 1
StatePublished - 2003

Fingerprint

Progressive Multifocal Leukoencephalopathy
India
HIV
Acquired Immunodeficiency Syndrome
JC Virus
Satellite Viruses
Virus Diseases
Population
Viruses
Incidence
Infection

Keywords

  • AIDS
  • HHV-6
  • HIV
  • JCV
  • PML
  • Tat

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Shankar, S. K., Satishchandra, P., Mahadevan, A., Yasha, T. C., Nagaraja, D., Taly, A. B., ... Nath, A. (2003). Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation? Journal of NeuroVirology, 9(SUPPL. 1), 59-67.

Low prevalence of progressive multifocal leukoencephalopathy in India and Africa : Is there a biological explanation? / Shankar, S. K.; Satishchandra, P.; Mahadevan, A.; Yasha, T. C.; Nagaraja, D.; Taly, A. B.; Prabhakar, S.; Nath, A.

In: Journal of NeuroVirology, Vol. 9, No. SUPPL. 1, 2003, p. 59-67.

Research output: Contribution to journalArticle

Shankar, SK, Satishchandra, P, Mahadevan, A, Yasha, TC, Nagaraja, D, Taly, AB, Prabhakar, S & Nath, A 2003, 'Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation?', Journal of NeuroVirology, vol. 9, no. SUPPL. 1, pp. 59-67.
Shankar SK, Satishchandra P, Mahadevan A, Yasha TC, Nagaraja D, Taly AB et al. Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation? Journal of NeuroVirology. 2003;9(SUPPL. 1):59-67.
Shankar, S. K. ; Satishchandra, P. ; Mahadevan, A. ; Yasha, T. C. ; Nagaraja, D. ; Taly, A. B. ; Prabhakar, S. ; Nath, A. / Low prevalence of progressive multifocal leukoencephalopathy in India and Africa : Is there a biological explanation?. In: Journal of NeuroVirology. 2003 ; Vol. 9, No. SUPPL. 1. pp. 59-67.
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