Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation?

S. K. Shankar, P. Satishchandra, A. Mahadevan, T. C. Yasha, D. Nagaraja, A. B. Taly, S. Prabhakar, A. Nath

Research output: Contribution to journalReview article

Abstract

Infection with human immunodeficiency virus (HIV) clade C virus is the most common form of HIV infection in the world. It largely infects populations in Africa and Asia and not much is known about the neurological complications associated with the virus. Cases of progressive multifocal leukoencephalopathy (PML) have been rarely reported in the literature in the acquired immunodeficiency syndrome (AIDS) or non-AIDS populations from these regions. In this article, the authors present three recently diagnosed patients with AIDS and PML from one neurological center in India, review the diagnostic challenges faced, and speculate on the possible biological-reasons, including viral strain differences as well as HIV and JC virus interactions, that may account for the low incidence.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalJournal of neurovirology
Volume9
Issue numberSUPPL. 1
StatePublished - Jun 13 2003

Keywords

  • AIDS
  • HHV-6
  • HIV
  • JCV
  • PML
  • Tat

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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  • Cite this

    Shankar, S. K., Satishchandra, P., Mahadevan, A., Yasha, T. C., Nagaraja, D., Taly, A. B., Prabhakar, S., & Nath, A. (2003). Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is there a biological explanation? Journal of neurovirology, 9(SUPPL. 1), 59-67.