Low plasma selenium concentrations and mortality among older community-dwelling adults: The InCHIANTI study

Fulvio Lauretani, Richard D. Semba, Stcfania Bandinelli, Amanda L. Ray, Carmelinda Ruggiero, Antonio Cherubini, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Aims: We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study. Methods: 1042 men and women ≥65 years from the InCHIANTI study, a population-based study of older adults living in the Chianti tegion of Tuscany, a population-based cohort in Tuscany, Italy. Plasma selenium was measured at enrollment (1998-2000), and vital status was ascertained until May 2006. Results: During follow-up, 237 participants (22.7%) died. At enrollment, mean (SD) plasma selenium concentrations among participants who survived or died were 0.96 (0.14) and 0.87 (0.18) μmol/L (p<0.0001), respectively. The proportion of participants who died, from lowest to highest quartile of selenium, was 41.3, 27.0, 18.1 and 13.5% (p<0.0001 by Mantel-Haenszel chi-square). After adjusting for age, sex, education, and chronic diseases, adults in the lowest quartile of plasma selenium at enrollment had higher mortality compared with those in the highest quartile (Hazard Ratio (HR) 1.60, 95% Confidence Interval (CI) 1.04-2.47, p=0.034). Conclusion: Low plasma selenium may be an independent predictor of mortality among older adults living in the community.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalAging Clinical and Experimental Research
Volume20
Issue number2
DOIs
StatePublished - Apr 2008

Keywords

  • Aging
  • Mortality
  • Selenium

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Lauretani, F., Semba, R. D., Bandinelli, S., Ray, A. L., Ruggiero, C., Cherubini, A., Guralnik, J. M., & Ferrucci, L. (2008). Low plasma selenium concentrations and mortality among older community-dwelling adults: The InCHIANTI study. Aging Clinical and Experimental Research, 20(2), 153-158. https://doi.org/10.1007/BF03324762