Low Plasma Klotho Concentrations and Decline of Knee Strength in Older Adults

Richard David Semba, Luigi Ferrucci, Kai Sun, Eleanor Marie Simonsick, Randi Turner, Iva Miljkovic, Tamara Harris, Ann V. Schwartz, Keiko Asao, Stephen Kritchevsky, Anne B. Newman

Research output: Contribution to journalArticle


Background. Although the "anti-aging hormone" klotho is associated with sarcopenia in mice, the relationship between klotho and muscle strength in older adults is not well known. Methods. Plasma klotho concentrations were measured in 2,734 older adults, aged 71-80 years, who participated in the Health, Aging and Body Composition Study, a prospective observational cohort study conducted in Memphis, TN and Pittsburgh, PA. Knee extension strength was measured using isokinetic dynamometry at baseline and follow-up 2 and 4 years later. Knee extension strength was normalized for weight. Results. At baseline, participants in the highest tertile of plasma klotho had higher knee extension strength (β =. 72, standard error [SE] =. 018, p

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number1
Publication statusPublished - Jul 15 2015



  • Aging
  • Klotho
  • Sarcopenia
  • Skeletal muscle strength

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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