Low physical function as a risk factor for incident diabetes mellitus and insulin resistance

Allison Longenberger; Jeong Youn Lim; Todd T. Brown; Alison Abraham; Frank J. Palella; Rita B. Effros; Trevor Orchard; Maria Mori Brooks; Lawrence A. Kingsley

doi:10.2217/fvl.11.15

Low physical function as a risk factor for incident diabetes mellitus and insulin resistance

Allison Longenberger, Jeong Youn Lim, Todd T. Brown, Alison Abraham, Frank J. Palella, Rita B. Effros, Trevor Orchard, Maria Mori Brooks, Lawrence A. Kingsley

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Data from 1790 HIV-infected and uninfected men in the Multicenter AIDS Cohort Study (MACS) were analyzed to evaluate relationships between physical function, incident diabetes mellitus (DM) and insulin resistance among HIV-infected and -uninfected men. DM was defined in two ways, using less stringent and more stringent criteria. The 10-item Physical Functioning Scale from the Short Form-36 Health Survey measured baseline physical function. Cumulative DM incidence was highest among HIV-uninfected and HIV-infected men with low physical function. Physical function was a risk factor for DM in HIV-uninfected men and remained so after controlling for BMI, DM family history and race. Among HIV-infected men, physical function was an independent risk factor for DM using the less stringent diabetes definition. This study supports our previous findings that low physical function is an important risk factor for DM in the MACS cohort.

Original language	English (US)
Pages (from-to)	439-449
Number of pages	11
Journal	Future Virology
Volume	6
Issue number	4
DOIs	https://doi.org/10.2217/fvl.11.15
State	Published - Apr 2011

Keywords

AIDS
HIV
diabetes mellitus
insulin resistance
physical function

ASJC Scopus subject areas

Virology

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10.2217/fvl.11.15

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title = "Low physical function as a risk factor for incident diabetes mellitus and insulin resistance",

abstract = "Data from 1790 HIV-infected and uninfected men in the Multicenter AIDS Cohort Study (MACS) were analyzed to evaluate relationships between physical function, incident diabetes mellitus (DM) and insulin resistance among HIV-infected and -uninfected men. DM was defined in two ways, using less stringent and more stringent criteria. The 10-item Physical Functioning Scale from the Short Form-36 Health Survey measured baseline physical function. Cumulative DM incidence was highest among HIV-uninfected and HIV-infected men with low physical function. Physical function was a risk factor for DM in HIV-uninfected men and remained so after controlling for BMI, DM family history and race. Among HIV-infected men, physical function was an independent risk factor for DM using the less stringent diabetes definition. This study supports our previous findings that low physical function is an important risk factor for DM in the MACS cohort.",

keywords = "AIDS, HIV, diabetes mellitus, insulin resistance, physical function",

author = "Allison Longenberger and Lim, {Jeong Youn} and Brown, {Todd T.} and Alison Abraham and Palella, {Frank J.} and Effros, {Rita B.} and Trevor Orchard and Brooks, {Maria Mori} and Kingsley, {Lawrence A.}",

note = "Funding Information: From the *Cardiology Service of the Veterans AdministnitlOn Hospital and the Department of Medicine and Cardiovascular Research Institute of the University of California; San Francisco. California and tOregon Health Sciences University, Portland, Oregon. ThIS work was supported by Grants HL28146 and GM07546 from the NatIOnal Heart, Lung, and Blood Institute, Bethesda, Maryla!1d and by the Veterans Administration Research ServIce, Washington, DC.",

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doi = "10.2217/fvl.11.15",

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AU - Orchard, Trevor

AU - Brooks, Maria Mori

AU - Kingsley, Lawrence A.

N1 - Funding Information: From the *Cardiology Service of the Veterans AdministnitlOn Hospital and the Department of Medicine and Cardiovascular Research Institute of the University of California; San Francisco. California and tOregon Health Sciences University, Portland, Oregon. ThIS work was supported by Grants HL28146 and GM07546 from the NatIOnal Heart, Lung, and Blood Institute, Bethesda, Maryla!1d and by the Veterans Administration Research ServIce, Washington, DC.

PY - 2011/4

Y1 - 2011/4

N2 - Data from 1790 HIV-infected and uninfected men in the Multicenter AIDS Cohort Study (MACS) were analyzed to evaluate relationships between physical function, incident diabetes mellitus (DM) and insulin resistance among HIV-infected and -uninfected men. DM was defined in two ways, using less stringent and more stringent criteria. The 10-item Physical Functioning Scale from the Short Form-36 Health Survey measured baseline physical function. Cumulative DM incidence was highest among HIV-uninfected and HIV-infected men with low physical function. Physical function was a risk factor for DM in HIV-uninfected men and remained so after controlling for BMI, DM family history and race. Among HIV-infected men, physical function was an independent risk factor for DM using the less stringent diabetes definition. This study supports our previous findings that low physical function is an important risk factor for DM in the MACS cohort.

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Low physical function as a risk factor for incident diabetes mellitus and insulin resistance

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Keywords

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