Low peptic ulcer and high gastric cancer prevalence in a developing country with a high prevalence of infection by helicobacter pylori

M. Burstein, E. Monge, R. León-Barúa, R. Lozano, R. Berendson, Robert H Gilman, H. Legua, C. Rodriguez

Research output: Contribution to journalArticle

Abstract

We compared the prevalence rates of peptic ulcer (duodenal and gastric) and gastric cancer in 1,796 dyspeptic Peruvian patients with those reported in 2,883 similar patients from developed countries. The prevalence of total peptic ulcer was significantly lower, and that of gastric cancer significantly higher, in the Peruvian patients. The prevalence of gastric ulcer was lower but not significantly so. We deduced that the significantly lower prevalence of total peptic ulcer was directly related to the low prevalence rate of duodenal ulcer. We hypothesize that the reason for these differences was probably a higher prevalence of Helicobacter pylori-associated chronic atrophic gastritis with hypochlorhydria in the Peruvian patients. Hypochlorhydria decreases the predisposition to peptic ulcer (especially duodenal ulcer), and chronic atrophic gastritis may predispose an individual to gastric cancer.

Original languageEnglish (US)
Pages (from-to)154-156
Number of pages3
JournalJournal of Clinical Gastroenterology
Volume13
Issue number2
StatePublished - 1991

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Peptic Ulcer
Helicobacter pylori
Developing Countries
Stomach Neoplasms
Infection
Achlorhydria
Atrophic Gastritis
Duodenal Ulcer
Stomach Ulcer
Developed Countries
Stomach

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Low peptic ulcer and high gastric cancer prevalence in a developing country with a high prevalence of infection by helicobacter pylori. / Burstein, M.; Monge, E.; León-Barúa, R.; Lozano, R.; Berendson, R.; Gilman, Robert H; Legua, H.; Rodriguez, C.

In: Journal of Clinical Gastroenterology, Vol. 13, No. 2, 1991, p. 154-156.

Research output: Contribution to journalArticle

Burstein, M, Monge, E, León-Barúa, R, Lozano, R, Berendson, R, Gilman, RH, Legua, H & Rodriguez, C 1991, 'Low peptic ulcer and high gastric cancer prevalence in a developing country with a high prevalence of infection by helicobacter pylori', Journal of Clinical Gastroenterology, vol. 13, no. 2, pp. 154-156.
Burstein, M. ; Monge, E. ; León-Barúa, R. ; Lozano, R. ; Berendson, R. ; Gilman, Robert H ; Legua, H. ; Rodriguez, C. / Low peptic ulcer and high gastric cancer prevalence in a developing country with a high prevalence of infection by helicobacter pylori. In: Journal of Clinical Gastroenterology. 1991 ; Vol. 13, No. 2. pp. 154-156.
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AU - León-Barúa, R.

AU - Lozano, R.

AU - Berendson, R.

AU - Gilman, Robert H

AU - Legua, H.

AU - Rodriguez, C.

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AB - We compared the prevalence rates of peptic ulcer (duodenal and gastric) and gastric cancer in 1,796 dyspeptic Peruvian patients with those reported in 2,883 similar patients from developed countries. The prevalence of total peptic ulcer was significantly lower, and that of gastric cancer significantly higher, in the Peruvian patients. The prevalence of gastric ulcer was lower but not significantly so. We deduced that the significantly lower prevalence of total peptic ulcer was directly related to the low prevalence rate of duodenal ulcer. We hypothesize that the reason for these differences was probably a higher prevalence of Helicobacter pylori-associated chronic atrophic gastritis with hypochlorhydria in the Peruvian patients. Hypochlorhydria decreases the predisposition to peptic ulcer (especially duodenal ulcer), and chronic atrophic gastritis may predispose an individual to gastric cancer.

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