Low molecular weight hyaluronan activates cytosolic phospholipase A 2α and eicosanoid production in monocytes and macrophages

Milena Sokolowska, Li Yuan Chen, Michael Eberlein, Asuncion Martinez-Anton, Yueqin Liu, Sara Alsaaty, Hai Yan Qi, Carolea Logun, Maureen Horton, James H. Shelhamer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.

Original languageEnglish (US)
Pages (from-to)4470-4488
Number of pages19
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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