Low molecular weight hyaluronan activates cytosolic phospholipase A 2α and eicosanoid production in monocytes and macrophages

Milena Sokolowska; Li Yuan Chen; Michael Eberlein; Asuncion Martinez-Anton; Yueqin Liu; Sara Alsaaty; Hai Yan Qi; Carolea Logun; Maureen Horton; James H. Shelhamer

doi:10.1074/jbc.M113.515106

Low molecular weight hyaluronan activates cytosolic phospholipase A ₂α and eicosanoid production in monocytes and macrophages

Milena Sokolowska, Li Yuan Chen, Michael Eberlein, Asuncion Martinez-Anton, Yueqin Liu, Sara Alsaaty, Hai Yan Qi, Carolea Logun, Maureen Horton, James H. Shelhamer

School of Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.

Original language	English (US)
Pages (from-to)	4470-4488
Number of pages	19
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.515106
State	Published - Feb 14 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Low molecular weight hyaluronan activates cytosolic phospholipase A 2α and eicosanoid production in monocytes and macrophages",

abstract = "Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.",

author = "Milena Sokolowska and Chen, {Li Yuan} and Michael Eberlein and Asuncion Martinez-Anton and Yueqin Liu and Sara Alsaaty and Qi, {Hai Yan} and Carolea Logun and Maureen Horton and Shelhamer, {James H.}",

year = "2014",

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doi = "10.1074/jbc.M113.515106",

language = "English (US)",

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T1 - Low molecular weight hyaluronan activates cytosolic phospholipase A 2α and eicosanoid production in monocytes and macrophages

AU - Sokolowska, Milena

AU - Chen, Li Yuan

AU - Eberlein, Michael

AU - Martinez-Anton, Asuncion

AU - Liu, Yueqin

AU - Alsaaty, Sara

AU - Qi, Hai Yan

AU - Logun, Carolea

AU - Horton, Maureen

AU - Shelhamer, James H.

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.

AB - Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.

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Low molecular weight hyaluronan activates cytosolic phospholipase A ₂α and eicosanoid production in monocytes and macrophages

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