Low maternal vitamin B-12 status is associated with offspring insulin resistance regardless of antenatal micronutrient supplementation in rural Nepal

Christine P. Stewart, Parul S Christian, Kerry J Schulze, Margia Arguello, Steven C. LeClerq, Subarna K. Khatry, Keith West

Research output: Contribution to journalArticle

Abstract

Questions have been raised about potentially negative effects of antenatal folic acid use in populations with a high prevalence of vitamin B-12 deficiency. Our objective was to examine the association between maternal folate and vitamin B-12 status in pregnancy on offspring insulin resistance and examine whether the effects of maternal micronutrient supplementation varied by baseline maternal folate and/or vitamin B-12 status. Pregnant women were cluster randomized to receive daily supplements containing vitamin A alone or with folic acid, folic acid+iron, folic acid+iron+zinc, or a multiple micronutrient. In a subsample (n = 1132), micronutrient status biomarkers were analyzed at baseline and late pregnancy. Children born to the women who participated in the trial were visited at 6-8 y of age. Fasting plasma glucose and insulin were used to estimate insulin resistance using the homeostasis model assessment (HOMA-IR). Children whose mothers were deficient in vitamin B-12 (

Original languageEnglish (US)
Pages (from-to)1912-1917
Number of pages6
JournalJournal of Nutrition
Volume141
Issue number10
DOIs
StatePublished - Oct 1 2011

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Nepal
Micronutrients
Vitamin B 12
Folic Acid
Insulin Resistance
Mothers
Iron
Vitamin B 12 Deficiency
Pregnancy
Vitamin A
Zinc
Pregnant Women
Fasting
Homeostasis
Biomarkers
Insulin
Glucose
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Low maternal vitamin B-12 status is associated with offspring insulin resistance regardless of antenatal micronutrient supplementation in rural Nepal. / Stewart, Christine P.; Christian, Parul S; Schulze, Kerry J; Arguello, Margia; LeClerq, Steven C.; Khatry, Subarna K.; West, Keith.

In: Journal of Nutrition, Vol. 141, No. 10, 01.10.2011, p. 1912-1917.

Research output: Contribution to journalArticle

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