Low-level viremia early in HIV infection

Iris Chen, Vanessa Cummings, Jessica M. Fogel, Mark A. Marzinke, William Clarke, Matthew B. Connor, Sam Griffith, Susan Buchbinder, Steven Shoptaw, Carlos Del Rio, Manya Magnus, Sharon Mannheimer, Darrell P. Wheeler, Kenneth H. Mayer, Beryl A. Koblin, Susan H. Eshleman

Research output: Contribution to journalArticlepeer-review

Abstract

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume67
Issue number4
DOIs
StatePublished - 2014

Keywords

  • Diagnosis
  • HIV
  • HIV controllers
  • Seroconversion
  • Viral load

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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