Low-level viremia early in HIV infection

Iris Chen; Vanessa Cummings; Jessica M. Fogel; Mark A. Marzinke; William Clarke; Matthew B. Connor; Sam Griffith; Susan Buchbinder; Steven Shoptaw; Carlos Del Rio; Manya Magnus; Sharon Mannheimer; Darrell P. Wheeler; Kenneth H. Mayer; Beryl A. Koblin; Susan H. Eshleman

doi:10.1097/QAI.0000000000000298

Low-level viremia early in HIV infection

Iris Chen, Vanessa Cummings, Jessica M. Fogel, Mark A. Marzinke, William Clarke, Matthew B. Connor, Sam Griffith, Susan Buchbinder, Steven Shoptaw, Carlos Del Rio, Manya Magnus, Sharon Mannheimer, Darrell P. Wheeler, Kenneth H. Mayer, Beryl A. Koblin, Susan H. Eshleman

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

Original language	English (US)
Pages (from-to)	405-408
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	67
Issue number	4
DOIs	https://doi.org/10.1097/QAI.0000000000000298
State	Published - 2014

Keywords

Diagnosis
HIV
HIV controllers
Seroconversion
Viral load

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0000000000000298

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Chen, I., Cummings, V., Fogel, J. M., Marzinke, M. A., Clarke, W., Connor, M. B., Griffith, S., Buchbinder, S., Shoptaw, S., Del Rio, C., Magnus, M., Mannheimer, S., Wheeler, D. P., Mayer, K. H., Koblin, B. A., & Eshleman, S. H. (2014). Low-level viremia early in HIV infection. Journal of Acquired Immune Deficiency Syndromes, 67(4), 405-408. https://doi.org/10.1097/QAI.0000000000000298

Chen, I, Cummings, V, Fogel, JM, Marzinke, MA , Clarke, W, Connor, MB, Griffith, S, Buchbinder, S, Shoptaw, S, Del Rio, C, Magnus, M, Mannheimer, S, Wheeler, DP, Mayer, KH, Koblin, BA & Eshleman, SH 2014, 'Low-level viremia early in HIV infection', Journal of Acquired Immune Deficiency Syndromes, vol. 67, no. 4, pp. 405-408. https://doi.org/10.1097/QAI.0000000000000298

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abstract = "HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.",

keywords = "Diagnosis, HIV, HIV controllers, Seroconversion, Viral load",

author = "Iris Chen and Vanessa Cummings and Fogel, {Jessica M.} and Marzinke, {Mark A.} and William Clarke and Connor, {Matthew B.} and Sam Griffith and Susan Buchbinder and Steven Shoptaw and {Del Rio}, Carlos and Manya Magnus and Sharon Mannheimer and Wheeler, {Darrell P.} and Mayer, {Kenneth H.} and Koblin, {Beryl A.} and Eshleman, {Susan H.}",

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language = "English (US)",

volume = "67",

pages = "405--408",

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AU - Chen, Iris

AU - Cummings, Vanessa

AU - Fogel, Jessica M.

AU - Marzinke, Mark A.

AU - Clarke, William

AU - Connor, Matthew B.

AU - Griffith, Sam

AU - Buchbinder, Susan

AU - Shoptaw, Steven

AU - Del Rio, Carlos

AU - Magnus, Manya

AU - Mannheimer, Sharon

AU - Wheeler, Darrell P.

AU - Mayer, Kenneth H.

AU - Koblin, Beryl A.

AU - Eshleman, Susan H.

PY - 2014

Y1 - 2014

N2 - HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

AB - HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

KW - Diagnosis

KW - HIV

KW - HIV controllers

KW - Seroconversion

KW - Viral load

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Low-level viremia early in HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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