Low-Intensity Pulsed Ultrasound as a Potential Adjuvant Therapy to Promote Spinal Fusion: Systematic Review and Meta-analysis of the Available Data

Ethan Cottrill, Max Downey, Zach Pennington, Jeff Ehresman, Andrew Schilling, Madison Downey, Andrew Hersh, Nicholas Theodore, Daniel M. Sciubba, Timothy Witham

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite extensive research, nonunion continues to affect a nontrivial proportion of patients undergoing spinal fusion. Recently, preclinical studies have suggested that low-intensity pulsed ultrasound (LIPUS) may increase rates of spinal fusion. In this study, we summarized the available in vivo literature evaluating the effect of LIPUS on spinal fusion and performed a meta-analysis of the available data to estimate the degree to which LIPUS may mediate higher fusion rates. Across 13 preclinical studies, LIPUS was associated with a 9-fold increase in the odds of successful spinal fusion. Future studies are necessary to establish the benefit of LIPUS on spinal fusion in clinical populations.

Original languageEnglish (US)
JournalJournal of Ultrasound in Medicine
DOIs
StateAccepted/In press - 2020

Keywords

  • low-intensity pulsed ultrasound
  • nonunion
  • pseudarthrosis
  • spinal fusion

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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