Low-grade squamous intraepithelial lesions

Cytologic predictors of biopsy confirmation

S. Hall, Tzyy Choou Wu, N. Soudi, M. E. Sherman

Research output: Contribution to journalArticle

Abstract

One hundred and seven smears demonstrating a low-grade squamous intraepithelial lesion (LSIL) were analyzed for features predicting subsequent biopsy confirmation. Twelve (29%) of 41 smears showing few LSIL cells were biopsy confirmed compared to 33 (60%) of 55 containing an intermediate number of LSIL cells and 9 (82%) of 11 displaying many LSIL cells (P <0.002). Thirty-seven (47%) of 78 smears showing mainly condylomatous atypia (CA), 7 (54%) of 13 revealing predominantly cervical intraepithelial neoplasia 1 (CIN 1), and 10 (63%) of 16 displaying both CA and CIN 1 were histologically confirmed (N.S.). Biopsy confirmation was obtained in 35 (65%) of 54 women whose repeat smears obtained at colposcopy demonstrated SIL compared to four (15%) of 26 patients whose repeat smears were normal or contained atypical squamous cells of undetermined significance (P <0.001). These results suggest that the number of diagnostic cells in an LSIL smear predicts biopsy confirmation and affirm the validity of combining CA and CIN 1 under the category of LSIL in the Bethesda System.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalDiagnostic Cytopathology
Volume10
Issue number1
StatePublished - 1994

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Biopsy
Cervical Intraepithelial Neoplasia
Colposcopy
Squamous Intraepithelial Lesions of the Cervix
Cell Count

Keywords

  • Cervical carcinoma
  • Cervical intraepithelial neoplasia
  • Cervix
  • Colposcopy
  • Condyloma
  • Cytology
  • Human papillomavirus
  • In situ hybridization
  • Squamous intraepithelial lesion
  • The Bethesda System

ASJC Scopus subject areas

  • Anatomy

Cite this

Low-grade squamous intraepithelial lesions : Cytologic predictors of biopsy confirmation. / Hall, S.; Wu, Tzyy Choou; Soudi, N.; Sherman, M. E.

In: Diagnostic Cytopathology, Vol. 10, No. 1, 1994, p. 3-9.

Research output: Contribution to journalArticle

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