Low-grade follicular lymphoma of the small intestine

Matthew M. Poggi, Peijie J. Cong, C. Norman Coleman, Elaine S. Jaffe

Research output: Contribution to journalArticle

Abstract

Background: Although the gastrointestinal tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), primary small intestine lymphomas remain relatively rare, especially localized low-grade follicular B-cell lymphomas. When lymphomas do occur at this site, most are high grade and require aggressive therapy. We report three cases of small intestinal follicular lymphoma diagnosed on endoscopic biopsy and review the clinical history, pathologic features, and treatment outcome. Study: A review of the medical records and pathology from three cases of small intestine follicular NHL was performed. The pathology specimens were formalin-fixed, paraffin-embedded tissues processed for routine microscopic examination, immunohistochemical staining, and molecular analysis. Results: Histologic and immunophenotypical studies were diagnostic of grade 1 follicular lymphoma (Revised European-American Lymphoma classification/World Health Organization classification). All cases expressed bcl-2 protein, and polymerase chain reaction analysis supported the diagnosis in two cases with adequate DNA. With 23.3 months' median follow-up, one untreated and one treated patient were alive without symptoms; a third untreated patient died of a nonlymphoma cause. Conclusion: Isolated indolent lymphomas of the small intestine are rare. Accurate pathologic staging and histologic classification are paramount in delineating treatment options.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume34
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Follicular Lymphoma
Non-Hodgkin's Lymphoma
Small Intestine
Lymphoma
Pathology
B-Cell Lymphoma
Paraffin
Formaldehyde
Medical Records
Gastrointestinal Tract
Staining and Labeling
Biopsy
Polymerase Chain Reaction
DNA
Therapeutics
Proteins

Keywords

  • Follicular
  • Intestine
  • Lymphoma
  • Real

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Low-grade follicular lymphoma of the small intestine. / Poggi, Matthew M.; Cong, Peijie J.; Coleman, C. Norman; Jaffe, Elaine S.

In: Journal of Clinical Gastroenterology, Vol. 34, No. 2, 2002, p. 155-159.

Research output: Contribution to journalArticle

Poggi, Matthew M. ; Cong, Peijie J. ; Coleman, C. Norman ; Jaffe, Elaine S. / Low-grade follicular lymphoma of the small intestine. In: Journal of Clinical Gastroenterology. 2002 ; Vol. 34, No. 2. pp. 155-159.
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