Low-grade clear cell renal cell carcinoma mimicking hemangioma of the kidney

A series of 4 cases

Oleksandr N. Kryvenko, Leonardo Roquero, Nilesh S. Gupta, Min W. Lee, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

Context. - Clear cell renal cell carcinoma (CCRCC) has a rich, sinusoid-like vascularity frequently used as a diagnostic criterion. CCRCC with predominantly vascular architecture has not been described. Objective. - To describe 4 unusual CCRCC cases, primarily presenting with hemangioma-like morphologic pattern. Design. - Clinicopathologic and selected immunohistochemical analysis of 4 cases of CCRCC mimicking hemangioma. Results. - Cases were seen in 1 woman and 3 men (average age, 48.8 years; range, 40-66 years). Grossly, tumors were red-brown (3 of 4) with scant bright-yellow foci in 1. The average tumor size was 4 cm (range, 2.5-5.5 cm). Microscopically, all were composed of varying proportions of a rich, arborizing, sinusoid-like vasculature with focal hobnail appearance of endothelial cells. Entrapment of renal tubules between blood vessels was seen at the periphery of the tumors. This morphology was reminiscent of anastomosing hemangioma. Isolated tumor cells resembling lymphocytes with clear halos were sparsely interspersed between vessels. Cytokeratin immunostain confirmed the diagnosis of CCRCC. Conclusion. - Extensive sampling and immunohistochemical workup of what is deemed to be a benign vascular neoplasm of the kidney is needed to rule out the presence of individual carcinoma cells or small viable carcinoma cell clusters.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume137
Issue number2
DOIs
StatePublished - Feb 2013

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Hemangioma
Renal Cell Carcinoma
Kidney
Neoplasms
Blood Vessels
Vascular Neoplasms
Small Cell Carcinoma
Keratins
Endothelial Cells
Lymphocytes
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Low-grade clear cell renal cell carcinoma mimicking hemangioma of the kidney : A series of 4 cases. / Kryvenko, Oleksandr N.; Roquero, Leonardo; Gupta, Nilesh S.; Lee, Min W.; Epstein, Jonathan Ira.

In: Archives of Pathology and Laboratory Medicine, Vol. 137, No. 2, 02.2013, p. 251-254.

Research output: Contribution to journalArticle

Kryvenko, Oleksandr N. ; Roquero, Leonardo ; Gupta, Nilesh S. ; Lee, Min W. ; Epstein, Jonathan Ira. / Low-grade clear cell renal cell carcinoma mimicking hemangioma of the kidney : A series of 4 cases. In: Archives of Pathology and Laboratory Medicine. 2013 ; Vol. 137, No. 2. pp. 251-254.
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