Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine

Lynn Morris; Candice Pillay; Claudia Chezzi; Pumla Lupondwana; Matshediso Ntsala; Leon Levin; Francois Venter; Neil Martinson; Glenda Gray; James McIntyre

doi:10.1097/00002030-200307250-00017

Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine

Lynn Morris, Candice Pillay, Claudia Chezzi, Pumla Lupondwana, Matshediso Ntsala, Leon Levin, Francois Venter, Neil Martinson, Glenda Gray, James McIntyre

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.

Original language	English (US)
Pages (from-to)	1698-1700
Number of pages	3
Journal	AIDS
Volume	17
Issue number	11
DOIs	https://doi.org/10.1097/00002030-200307250-00017
State	Published - Jul 25 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1097/00002030-200307250-00017

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title = "Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine",

abstract = "Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.",

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T1 - Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine

AU - Morris, Lynn

AU - Pillay, Candice

AU - Chezzi, Claudia

AU - Lupondwana, Pumla

AU - Ntsala, Matshediso

AU - Levin, Leon

AU - Venter, Francois

AU - Martinson, Neil

AU - Gray, Glenda

AU - McIntyre, James

PY - 2003/7/25

Y1 - 2003/7/25

N2 - Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.

AB - Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.

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JO - AIDS

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ER -

Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine

Abstract

ASJC Scopus subject areas

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