Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine

Lynn Morris, Candice Pillay, Claudia Chezzi, Pumla Lupondwana, Matshediso Ntsala, Leon Levin, Francois Venter, Neil Martinson, Glenda Gray, James McIntyre

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Abstract

Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.

Original languageEnglish (US)
Pages (from-to)1698-1700
Number of pages3
JournalAIDS
Volume17
Issue number11
DOIs
Publication statusPublished - Jul 25 2003

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Morris, L., Pillay, C., Chezzi, C., Lupondwana, P., Ntsala, M., Levin, L., ... McIntyre, J. (2003). Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine. AIDS, 17(11), 1698-1700. https://doi.org/10.1097/00002030-200307250-00017