Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy

Junichi Yamamoto; Akio Ikeda; Takeshi Satow; Kazuhide Takeshita; Motohiro Takayama; Masao Matsuhashi; Riki Matsumoto; Shinji Ohara; Nobuhiro Mikuni; Jun Takahashi; Susumu Miyamoto; Waro Taki; Nobuo Hashimoto; John C. Rothwell; Hiroshi Shibasaki

doi:10.1046/j.1528-1157.2002.29001.x

Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy

Junichi Yamamoto, Akio Ikeda, Takeshi Satow, Kazuhide Takeshita, Motohiro Takayama, Masao Matsuhashi, Riki Matsumoto, Shinji Ohara, Nobuhiro Mikuni, Jun Takahashi, Susumu Miyamoto, Waro Taki, Nobuo Hashimoto, John C. Rothwell, Hiroshi Shibasaki

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.

Original language	English (US)
Pages (from-to)	491-495
Number of pages	5
Journal	Epilepsia
Volume	43
Issue number	5
DOIs	https://doi.org/10.1046/j.1528-1157.2002.29001.x
State	Published - 2002
Externally published	Yes

Keywords

Inhibitory effects
Interictal epileptiform discharge
Intractable epilepsy
Low-frequency electric cortical stimulation
Subdural electrode

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1046/j.1528-1157.2002.29001.x

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Yamamoto, J., Ikeda, A., Satow, T., Takeshita, K., Takayama, M., Matsuhashi, M., Matsumoto, R., Ohara, S., Mikuni, N., Takahashi, J., Miyamoto, S., Taki, W., Hashimoto, N., Rothwell, J. C., & Shibasaki, H. (2002). Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. Epilepsia, 43(5), 491-495. https://doi.org/10.1046/j.1528-1157.2002.29001.x

Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. / Yamamoto, Junichi; Ikeda, Akio; Satow, Takeshi; Takeshita, Kazuhide; Takayama, Motohiro; Matsuhashi, Masao; Matsumoto, Riki; Ohara, Shinji; Mikuni, Nobuhiro; Takahashi, Jun; Miyamoto, Susumu; Taki, Waro; Hashimoto, Nobuo; Rothwell, John C.; Shibasaki, Hiroshi.

In: Epilepsia, Vol. 43, No. 5, 2002, p. 491-495.

Research output: Contribution to journal › Article › peer-review

Yamamoto, J, Ikeda, A, Satow, T, Takeshita, K, Takayama, M, Matsuhashi, M, Matsumoto, R, Ohara, S, Mikuni, N, Takahashi, J, Miyamoto, S, Taki, W, Hashimoto, N, Rothwell, JC & Shibasaki, H 2002, 'Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy', Epilepsia, vol. 43, no. 5, pp. 491-495. https://doi.org/10.1046/j.1528-1157.2002.29001.x

Yamamoto, Junichi ; Ikeda, Akio ; Satow, Takeshi ; Takeshita, Kazuhide ; Takayama, Motohiro ; Matsuhashi, Masao ; Matsumoto, Riki ; Ohara, Shinji ; Mikuni, Nobuhiro ; Takahashi, Jun ; Miyamoto, Susumu ; Taki, Waro ; Hashimoto, Nobuo ; Rothwell, John C. ; Shibasaki, Hiroshi. / Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. In: Epilepsia. 2002 ; Vol. 43, No. 5. pp. 491-495.

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abstract = "Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.",

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AU - Yamamoto, Junichi

AU - Ikeda, Akio

AU - Satow, Takeshi

AU - Takeshita, Kazuhide

AU - Takayama, Motohiro

AU - Matsuhashi, Masao

AU - Matsumoto, Riki

AU - Ohara, Shinji

AU - Mikuni, Nobuhiro

AU - Takahashi, Jun

AU - Miyamoto, Susumu

AU - Taki, Waro

AU - Hashimoto, Nobuo

AU - Rothwell, John C.

AU - Shibasaki, Hiroshi

PY - 2002

Y1 - 2002

N2 - Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.

AB - Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.

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KW - Interictal epileptiform discharge

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KW - Low-frequency electric cortical stimulation

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Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy

Abstract

Keywords

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