Abstract
Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-495 |
| Number of pages | 5 |
| Journal | Epilepsia |
| Volume | 43 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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Keywords
- Inhibitory effects
- Interictal epileptiform discharge
- Intractable epilepsy
- Low-frequency electric cortical stimulation
- Subdural electrode
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. / Yamamoto, Junichi; Ikeda, Akio; Satow, Takeshi; Takeshita, Kazuhide; Takayama, Motohiro; Matsuhashi, Masao; Matsumoto, Riki; Ohara, Shinji; Mikuni, Nobuhiro; Takahashi, Jun; Miyamoto, Susumu; Taki, Waro; Hashimoto, Nobuo; Rothwell, John C.; Shibasaki, Hiroshi.
In: Epilepsia, Vol. 43, No. 5, 2002, p. 491-495.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy
AU - Yamamoto, Junichi
AU - Ikeda, Akio
AU - Satow, Takeshi
AU - Takeshita, Kazuhide
AU - Takayama, Motohiro
AU - Matsuhashi, Masao
AU - Matsumoto, Riki
AU - Ohara, Shinji
AU - Mikuni, Nobuhiro
AU - Takahashi, Jun
AU - Miyamoto, Susumu
AU - Taki, Waro
AU - Hashimoto, Nobuo
AU - Rothwell, John C.
AU - Shibasaki, Hiroshi
PY - 2002
Y1 - 2002
N2 - Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.
AB - Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.
KW - Inhibitory effects
KW - Interictal epileptiform discharge
KW - Intractable epilepsy
KW - Low-frequency electric cortical stimulation
KW - Subdural electrode
UR - http://www.scopus.com/inward/record.url?scp=0036091154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036091154&partnerID=8YFLogxK
U2 - 10.1046/j.1528-1157.2002.29001.x
DO - 10.1046/j.1528-1157.2002.29001.x
M3 - Article
C2 - 12027909
AN - SCOPUS:0036091154
VL - 43
SP - 491
EP - 495
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 5
ER -