Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy

Junichi Yamamoto, Akio Ikeda, Takeshi Satow, Kazuhide Takeshita, Motohiro Takayama, Masao Matsuhashi, Riki Matsumoto, Shinji Ohara, Nobuhiro Mikuni, Jun Takahashi, Susumu Miyamoto, Waro Taki, Nobuo Hashimoto, John C. Rothwell, Hiroshi Shibasaki

Research output: Contribution to journalArticle

Abstract

Purpose: This study was conducted to investigate the effect of low-frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means of subdural electrodes and evaluated the change in the number of interictal epileptiform discharges. We used biphasic electric current of 0.3-ms duration presented at 0.9-Hz frequency for 250 s, comparing stimulus intensity of 7.5, 2, and 0.5 mA. Results: Interictal epileptiform discharges at the ictal focus occurred less frequently after the stimulation with the intensity of 0.5 mA. With the intensity of 7.5 mA and 2.0 mA, however, habitual auras were elicited by the stimulation, and afterdischarges were seen on the cortical EEG. Conclusions: Low-frequency, low-intensity electric cortical stimulation could produce inhibitory effects on epileptic activity. At the same time, however, a caution for possible induction of EEG seizures is needed, even when applying low-frequency electric stimulation.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalEpilepsia
Volume43
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

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Temporal Lobe Epilepsy
Electric Stimulation
Electroencephalography
Epilepsy
Electrodes
Seizures
Stroke

Keywords

  • Inhibitory effects
  • Interictal epileptiform discharge
  • Intractable epilepsy
  • Low-frequency electric cortical stimulation
  • Subdural electrode

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Yamamoto, J., Ikeda, A., Satow, T., Takeshita, K., Takayama, M., Matsuhashi, M., ... Shibasaki, H. (2002). Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. Epilepsia, 43(5), 491-495. https://doi.org/10.1046/j.1528-1157.2002.29001.x

Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. / Yamamoto, Junichi; Ikeda, Akio; Satow, Takeshi; Takeshita, Kazuhide; Takayama, Motohiro; Matsuhashi, Masao; Matsumoto, Riki; Ohara, Shinji; Mikuni, Nobuhiro; Takahashi, Jun; Miyamoto, Susumu; Taki, Waro; Hashimoto, Nobuo; Rothwell, John C.; Shibasaki, Hiroshi.

In: Epilepsia, Vol. 43, No. 5, 2002, p. 491-495.

Research output: Contribution to journalArticle

Yamamoto, J, Ikeda, A, Satow, T, Takeshita, K, Takayama, M, Matsuhashi, M, Matsumoto, R, Ohara, S, Mikuni, N, Takahashi, J, Miyamoto, S, Taki, W, Hashimoto, N, Rothwell, JC & Shibasaki, H 2002, 'Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy', Epilepsia, vol. 43, no. 5, pp. 491-495. https://doi.org/10.1046/j.1528-1157.2002.29001.x
Yamamoto, Junichi ; Ikeda, Akio ; Satow, Takeshi ; Takeshita, Kazuhide ; Takayama, Motohiro ; Matsuhashi, Masao ; Matsumoto, Riki ; Ohara, Shinji ; Mikuni, Nobuhiro ; Takahashi, Jun ; Miyamoto, Susumu ; Taki, Waro ; Hashimoto, Nobuo ; Rothwell, John C. ; Shibasaki, Hiroshi. / Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy. In: Epilepsia. 2002 ; Vol. 43, No. 5. pp. 491-495.
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AU - Takayama, Motohiro

AU - Matsuhashi, Masao

AU - Matsumoto, Riki

AU - Ohara, Shinji

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AU - Rothwell, John C.

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