Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn's Disease

Eran Zittan, Orlaith B. Kelly, Richard Kirsch, Raquel Milgrom, Jane Burns, Geoffrey C. Nguyen, Ken Croitoru, Gert Van Assche, Mark S. Silverberg, A. Hillary Steinhart

Research output: Contribution to journalArticle

Abstract

Data regarding the correlation of histologic and endoscopic healing with fecal calprotectin (FC) are conflicting. We examined how FC levels correlate with histological and endoscopic remission in colonic inflammatory bowel disease. Methods: Fifty-eight patients (23 with colonic Crohn's disease [CD] and 35 with ulcerative colitis [UC]) were included. Clinical activity was assessed by Harvey-Bradshaw index (CD) and Mayo score (UC). Inflammatory activity was assessed by ileocolonoscopy, C-reactive protein, and FC. Clinical remission was defined as Harvey-Bradshaw index ≤ 4 or Mayo score ≤ 2 and mucosal healing as Mayo endoscopic subscore = 0 (UC), and Simple Endoscopic Score-CD

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalInflammatory Bowel Diseases
Volume22
Issue number3
DOIs
StatePublished - Nov 23 2015
Externally publishedYes

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Keywords

  • Crohn's colitis
  • Fecal calprotectin
  • histological remission
  • ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Zittan, E., Kelly, O. B., Kirsch, R., Milgrom, R., Burns, J., Nguyen, G. C., Croitoru, K., Van Assche, G., Silverberg, M. S., & Steinhart, A. H. (2015). Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn's Disease. Inflammatory Bowel Diseases, 22(3), 623-630. https://doi.org/10.1097/MIB.0000000000000652