"low-fat" pseudoangiomatous spindle cell lipoma: A rare variant with loss of 13q14 region

Jessica A. Forcucci, Jessica Z. Sugianto, Daynna J. Wolff, John C. Maize, Jonathan S. Ralston

Research output: Contribution to journalArticlepeer-review

Abstract

Spindle cell and pleomorphic lipoma constitute a spectrum of lipomatous lesions with characteristic clinical, morphologic, immunohistochemical, and molecular features. Multiple variants have been previously described including vascular, fibrous, plexiform, and those with significantly less fat termed "low-fat" and "fat-free" by Folpe. Cytogenetically, spindle cell lipomas frequently display monoallelic loss of 13q14 region, an abnormality also found in cellular angiofibroma and mammary-Type myofibroblastoma. Pseudoangiomatous spindle cell lipoma, originally described by Fletcher et al in 1994, is a rare variant within the spindle cell/pleomorphic lipoma spectrum, with less than 20 published cases. It consists of an admixture of spindle cells, "ropey" collagen, variable amounts of mature fat, and irregular, branching slit-like vascular spaces. The authors present a case of a 1-cm subcutaneous lesion excised from the neck of a 70-year-old man with classic histologic and immunohistochemical features of "low-fat" pseudoangiomatous spindle cell lipoma. Fluorescence in situ hybridization demonstrated a loss of 13q14 region, a characteristic presumed cytogenetic finding of spindle cell lipoma, which has been previously unconfirmed in this variant.

Original languageEnglish (US)
Pages (from-to)920-923
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume37
Issue number12
DOIs
StatePublished - 2015

Keywords

  • 13q14
  • fluorescence in situ hybridization
  • pseudoangiomatous
  • spindle cell lipoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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