Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects

M. E. Newman, Q. Li, Y. Gelfin, L. D. Van de Kar, B. Lerer

Research output: Contribution to journalArticle

Abstract

Objective: The present study investigated whether administration of a 5- HT(1A) receptor agonist would increase growth hormone (GH) and oxytocin levels in normal human subjects, and whether the responses would be modified according to the age and gender of the subjects. Methods: Ipsapirone (0.3 mg/kg body weight), or placebo was administered to 30 normal subjects (14 males, 19-74 years and 16 females, 22-69 years) using a randomized, double blind design. Results: Stimulation of GH secretion by ipsapirone was significantly greater in male compared to female subjects, with no apparent effect of age. Oxytocin secretion was not stimulated by ipsapirone compared to placebo in any of the groups. Conclusions: The effects of gender and age on the degree of stimulation of GH secretion by 5-HT(1A) agonists in human subjects differ from their effects on secretion of the hormones ACTH and cortisol. A higher dose of ipsapirone is required to stimulate oxytocin secretion in normal human subjects.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalPsychopharmacology
Volume145
Issue number1
DOIs
StatePublished - Jul 29 1999
Externally publishedYes

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Keywords

  • 5-HT(1A) receptor
  • Growth hormone
  • Ipsapirone
  • Oxytocin
  • Serotonin (5-HT)

ASJC Scopus subject areas

  • Pharmacology

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