Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease

Alexander Gabrovsky, Abimbole Aderinto, Melissa R Spevak, Elliot Vichinsky, Linda M Smith Resar

Research output: Contribution to journalArticle

Abstract

Renal papillary necrosis in sickling hemoglobinopathies can lead to significant complications, including hemorrhage, obstruction, and infection. Despite its frequency, there are limited therapies for protracted hemorrhage. In the past, massive hemorrhage was managed with nephrectomy. Here, we report a patient with hemoglobin SC disease and prolonged, life-threatening hemorrhage from papillary necrosis successfully treated with oral, low-dose epsilon aminocaproic acid (EACA). Although further study is warranted, this case illustrates the need to consider EACA in the conservative management of renal papillary necrosis and significant hemorrhage in sickle cell hemoglobinopathies.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalPediatric Blood and Cancer
Volume54
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Hemoglobin SC Disease
Aminocaproic Acid
Necrosis
Hemorrhage
Kidney
Hemoglobinopathies
Nephrectomy
Infection

Keywords

  • Epsilon aminocaproic acid (Amicar®)
  • Hemoglobin SC
  • Hemorrhage
  • Papillary necrosis

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

Cite this

Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease. / Gabrovsky, Alexander; Aderinto, Abimbole; Spevak, Melissa R; Vichinsky, Elliot; Smith Resar, Linda M.

In: Pediatric Blood and Cancer, Vol. 54, No. 1, 01.2010, p. 148-150.

Research output: Contribution to journalArticle

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