Low-density lipoprotein cholesterol in high-risk asymptomatic individuals.

Juan J. Rivera, Roger S. Blumenthal, Dominique Ashen

Research output: Contribution to journalReview articlepeer-review


Cardiovascular disease claims more lives each year than the other 4 leading causes of death combined. Current prevention and treatment models focus on low-density lipoprotein cholesterol (LDL-C). In 2001, the National Cholesterol Education Program/Adult Treatment Panel III established new risk categories as well as new LDL-C targets especially for high-risk individuals. Since the implementation of these new guidelines, several relevant clinical trials have been published. The results of these trials suggest that lower LDL-C levels confer a more favorable cardiovascular outcome in high-risk individuals. The idea that low levels of LDL-C are related to a halt in atherosclerosis or even plaque regression has been entertained and investigated. Recent studies conducted exclusively on individuals with known diabetes have provided an important insight on how to appropriately manage diabetic dyslipidemia.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalJournal of the CardioMetabolic Syndrome
Issue number1
StatePublished - 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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