Low-density lipoprotein cholesterol in high-risk asymptomatic individuals.

Juan J. Rivera; Roger S. Blumenthal; Dominique Ashen

doi:10.1111/j.1559-4564.2007.06108.x

Low-density lipoprotein cholesterol in high-risk asymptomatic individuals.

Juan J. Rivera, Roger S. Blumenthal, Dominique Ashen

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Cardiovascular disease claims more lives each year than the other 4 leading causes of death combined. Current prevention and treatment models focus on low-density lipoprotein cholesterol (LDL-C). In 2001, the National Cholesterol Education Program/Adult Treatment Panel III established new risk categories as well as new LDL-C targets especially for high-risk individuals. Since the implementation of these new guidelines, several relevant clinical trials have been published. The results of these trials suggest that lower LDL-C levels confer a more favorable cardiovascular outcome in high-risk individuals. The idea that low levels of LDL-C are related to a halt in atherosclerosis or even plaque regression has been entertained and investigated. Recent studies conducted exclusively on individuals with known diabetes have provided an important insight on how to appropriately manage diabetic dyslipidemia.

Original language	English (US)
Pages (from-to)	49-52
Number of pages	4
Journal	Journal of the CardioMetabolic Syndrome
Volume	2
Issue number	1
DOIs	https://doi.org/10.1111/j.1559-4564.2007.06108.x
State	Published - 2007

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

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abstract = "Cardiovascular disease claims more lives each year than the other 4 leading causes of death combined. Current prevention and treatment models focus on low-density lipoprotein cholesterol (LDL-C). In 2001, the National Cholesterol Education Program/Adult Treatment Panel III established new risk categories as well as new LDL-C targets especially for high-risk individuals. Since the implementation of these new guidelines, several relevant clinical trials have been published. The results of these trials suggest that lower LDL-C levels confer a more favorable cardiovascular outcome in high-risk individuals. The idea that low levels of LDL-C are related to a halt in atherosclerosis or even plaque regression has been entertained and investigated. Recent studies conducted exclusively on individuals with known diabetes have provided an important insight on how to appropriately manage diabetic dyslipidemia.",

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AB - Cardiovascular disease claims more lives each year than the other 4 leading causes of death combined. Current prevention and treatment models focus on low-density lipoprotein cholesterol (LDL-C). In 2001, the National Cholesterol Education Program/Adult Treatment Panel III established new risk categories as well as new LDL-C targets especially for high-risk individuals. Since the implementation of these new guidelines, several relevant clinical trials have been published. The results of these trials suggest that lower LDL-C levels confer a more favorable cardiovascular outcome in high-risk individuals. The idea that low levels of LDL-C are related to a halt in atherosclerosis or even plaque regression has been entertained and investigated. Recent studies conducted exclusively on individuals with known diabetes have provided an important insight on how to appropriately manage diabetic dyslipidemia.

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Low-density lipoprotein cholesterol in high-risk asymptomatic individuals.

Abstract

ASJC Scopus subject areas

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