Low-density lipoprotein 4: a novel predictor of coronary artery disease severity

Rahul Chaudhary, Denny Mathew, Kevin Bliden, Udaya S. Tantry, Tushar Sharma, Martin G. Gesheff, Christopher J. Franzese, Shachi Pandya, Peter P. Toth, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

Background: Hyperlipidemia is a well established risk factor for coronary artery disease (CAD). Severe CAD has been observed in patients with normal levels of total and low-density lipoprotein (LDL) cholesterol. Small dense LDL particle subtypes (LDL3 and LDL4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. Methods: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients with suspected CAD. Detailed lipid profiling was performed using a VAP cholesterol test. CAD severity was categorized angiographically as no/minor CAD (<20% luminal diameter stenosis [LDS]), moderate CAD (20% to 74% LDS) and severe CAD (>75% LDS of any major coronary vessel). Results: Patients with severe CAD had significantly higher LDL4 and triglycerides, and lower total HDL, HDL2, HDL3, LDL2 and LDL3 compared to patients with no/minor CAD (p <.05 for all). Multivariate analysis showed high LDL4 as an independent predictive of severe CAD. ROC analysis showed an area under the curve of 0.62 (p <.0001) with a cut-point of >16.9 mg/dL to predict severe CAD with a sensitivity of 53% and specificity of 79%. Conclusion: Elevated LDL4 levels are associated with severe CAD. Further large-scale investigations are required to evaluate the utility of LDL4 in predicting CAD severity.

Original languageEnglish (US)
Pages (from-to)1979-1984
Number of pages6
JournalCurrent Medical Research and Opinion
Volume33
Issue number11
DOIs
StatePublished - Nov 2 2017

Keywords

  • cholesterol
  • Coronary artery disease
  • LDL subtypes
  • LDL4

ASJC Scopus subject areas

  • Medicine(all)

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    Chaudhary, R., Mathew, D., Bliden, K., Tantry, U. S., Sharma, T., Gesheff, M. G., Franzese, C. J., Pandya, S., Toth, P. P., & Gurbel, P. A. (2017). Low-density lipoprotein 4: a novel predictor of coronary artery disease severity. Current Medical Research and Opinion, 33(11), 1979-1984. https://doi.org/10.1080/03007995.2017.1365052