Low CSF 5-hydroxyindoleacetic acid in schizophrenic patients with enlarged cerebral ventricles

S. G. Potkin, D. R. Weinberger, M. Linnoila, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

The authors assayed CSF 5-hydroxyindoleacetic acid (5-HIAA) concentrations in 24 chronic schizophrenic patients, 9 of whom had enlarged cerebral ventricles according to computerized tomography scans, and in 15 control subjects with neurological disorders. Although there were no overall differences between the schizophrenic patients and the control subjects, schizophrenic patients with enlarged ventricles had significantly lower 5-HIAA concentrations. Also, ventricular size correlated inversely with 5-HIAA concentrations. The findings are consistent with other evidence that cerebral ventricular size is biologically meaningful in schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalAmerican Journal of Psychiatry
Volume140
Issue number1
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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