Low cholesterol concentrations and severe depressive symptoms in elderly people

S. Lori Brown, Marcel E. Salive, Tamara B. Harris, Eleanor Marie Simonsick, Jack M. Guralnik, Frank J. Kohout

Research output: Contribution to journalArticle

Abstract

Objective - To investigate the reported association between low serum cholestrol concentration and severe depressive symptoms in an elderly population. Design - Cross sectional analysis of pooled data from three communities of the established populations for epidemiologic studies of the elderly. Participants who completed their interview, including the Centers for Epidemiologic Studies' depression scale and consented to measurement of their cholesterol concentration were included in the study. Subjects - 3939 men and women aged ≥ 71. Methods - χ2 analysis, t tests, and multivariate regression analysis of the association between low cholesterol concentration and severe depressive symptoms. All analyses were stratified by sex, and multivariate analyses were adjusted for age, self reported health, physical function, number of drugs used, and weight loss. Main outcome measure - Score of depressive symptoms on the Centers for Epidemiologic Studies' depression scale. Results - Depressive symptoms, cholesterol concentration, weight, and use of drugs were all associated with age in men and women. The relative odds of severe depressive symptoms (score ≥ 16) for those with low cholesterol concentrations (<4.14 mmol/l) were 1.9 (95% confidence interval, 1.1 to 3.3) for the older group of men and 1.8 (1.1 to 2.9) for the older group of women. This association was also observed when depressive symptoms were analysed as a continuous rather than a categorical variable. In multivariate models that adjusted for age, self reported health, physical function, number of drugs used, and weight loss, the association was substantially weakened. Conclusions - After several factors relating to health had been controlled for, no significant association between low cholesterol concentration and severe depressive symptoms was found.

Original languageEnglish (US)
Pages (from-to)1328-1332
Number of pages5
JournalBMJ (Online)
Volume308
Issue number6940
StatePublished - May 21 1994
Externally publishedYes

Fingerprint

Cholesterol
cholesterol
Depression
epidemiological studies
drugs
Anti-Obesity Agents
weight loss
Epidemiologic Studies
cross-sectional studies
Health
Multivariate Analysis
confidence interval
interviews
regression analysis
gender
Population
Cross-Sectional Studies
Odds Ratio
Regression Analysis
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)
  • Agricultural and Biological Sciences(all)

Cite this

Brown, S. L., Salive, M. E., Harris, T. B., Simonsick, E. M., Guralnik, J. M., & Kohout, F. J. (1994). Low cholesterol concentrations and severe depressive symptoms in elderly people. BMJ (Online), 308(6940), 1328-1332.

Low cholesterol concentrations and severe depressive symptoms in elderly people. / Brown, S. Lori; Salive, Marcel E.; Harris, Tamara B.; Simonsick, Eleanor Marie; Guralnik, Jack M.; Kohout, Frank J.

In: BMJ (Online), Vol. 308, No. 6940, 21.05.1994, p. 1328-1332.

Research output: Contribution to journalArticle

Brown, SL, Salive, ME, Harris, TB, Simonsick, EM, Guralnik, JM & Kohout, FJ 1994, 'Low cholesterol concentrations and severe depressive symptoms in elderly people', BMJ (Online), vol. 308, no. 6940, pp. 1328-1332.
Brown SL, Salive ME, Harris TB, Simonsick EM, Guralnik JM, Kohout FJ. Low cholesterol concentrations and severe depressive symptoms in elderly people. BMJ (Online). 1994 May 21;308(6940):1328-1332.
Brown, S. Lori ; Salive, Marcel E. ; Harris, Tamara B. ; Simonsick, Eleanor Marie ; Guralnik, Jack M. ; Kohout, Frank J. / Low cholesterol concentrations and severe depressive symptoms in elderly people. In: BMJ (Online). 1994 ; Vol. 308, No. 6940. pp. 1328-1332.
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