Low carotenoid concentration and the risk of HIV seroconversion in Pune, India

Sanjay M. Mehendale, Mary E. Shepherd, Ronald S. Brookmeyer, Richard David Semba, Anand D. Divekar, Raman R. Gangakhedkar, Smita Joshi, Arun R. Risbud, Ramesh S. Paranjape, Deepak A. Gadkari, Robert C Bollinger

Research output: Contribution to journalArticle

Abstract

Low vitamin A and carotenoid levels could increase the risk of sexual HIV acquisition by altering the integrity of the genital epithelium or by immunologic dysfunction. We addressed this issue by measuring serum vitamin A and carotenoid levels in patients who were at risk of subsequent HIV infection. In a nested case-control study in individuals attending two sexually transmitted disease (STD) clinics in Pune, India, serum micronutrient levels were measured in 44 cases with documented HIV seroconversion (11 women and 33 men) and in STD patients matched for gender and length of follow-up with no subsequent HIV seroconversion (controls). STD patients in Pune had low vitamin A and carotenoid levels, and low serum β-carotene levels were independently associated with an increased risk of subsequent HIV seroconversion. STD patients with β-carotene levels less than 0.075 μmol/L were 21 times more likely to acquire HIV infection than those with higher levels (adjusted odds ratio = 21.1; p = .01). No such association was observed in case of other non-provitamin A carotenoids. This study reports the first evidence of an association between low serum provitamin A carotenoid levels and an increased risk for heterosexual HIV acquisition in STD patients in Pune, India.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume26
Issue number4
StatePublished - Apr 1 2001

Fingerprint

HIV Seropositivity
Carotenoids
India
Sexually Transmitted Diseases
Vitamin A
Serum
HIV Infections
HIV
Micronutrients
Heterosexuality
Case-Control Studies
Epithelium
Odds Ratio

Keywords

  • Carotenoids
  • Seroconversion
  • Vitamin A

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Mehendale, S. M., Shepherd, M. E., Brookmeyer, R. S., Semba, R. D., Divekar, A. D., Gangakhedkar, R. R., ... Bollinger, R. C. (2001). Low carotenoid concentration and the risk of HIV seroconversion in Pune, India. Journal of Acquired Immune Deficiency Syndromes, 26(4), 352-359.

Low carotenoid concentration and the risk of HIV seroconversion in Pune, India. / Mehendale, Sanjay M.; Shepherd, Mary E.; Brookmeyer, Ronald S.; Semba, Richard David; Divekar, Anand D.; Gangakhedkar, Raman R.; Joshi, Smita; Risbud, Arun R.; Paranjape, Ramesh S.; Gadkari, Deepak A.; Bollinger, Robert C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 26, No. 4, 01.04.2001, p. 352-359.

Research output: Contribution to journalArticle

Mehendale, SM, Shepherd, ME, Brookmeyer, RS, Semba, RD, Divekar, AD, Gangakhedkar, RR, Joshi, S, Risbud, AR, Paranjape, RS, Gadkari, DA & Bollinger, RC 2001, 'Low carotenoid concentration and the risk of HIV seroconversion in Pune, India', Journal of Acquired Immune Deficiency Syndromes, vol. 26, no. 4, pp. 352-359.
Mehendale SM, Shepherd ME, Brookmeyer RS, Semba RD, Divekar AD, Gangakhedkar RR et al. Low carotenoid concentration and the risk of HIV seroconversion in Pune, India. Journal of Acquired Immune Deficiency Syndromes. 2001 Apr 1;26(4):352-359.
Mehendale, Sanjay M. ; Shepherd, Mary E. ; Brookmeyer, Ronald S. ; Semba, Richard David ; Divekar, Anand D. ; Gangakhedkar, Raman R. ; Joshi, Smita ; Risbud, Arun R. ; Paranjape, Ramesh S. ; Gadkari, Deepak A. ; Bollinger, Robert C. / Low carotenoid concentration and the risk of HIV seroconversion in Pune, India. In: Journal of Acquired Immune Deficiency Syndromes. 2001 ; Vol. 26, No. 4. pp. 352-359.
@article{e1b7572f5d544f01ba12c2c04f474f7c,
title = "Low carotenoid concentration and the risk of HIV seroconversion in Pune, India",
abstract = "Low vitamin A and carotenoid levels could increase the risk of sexual HIV acquisition by altering the integrity of the genital epithelium or by immunologic dysfunction. We addressed this issue by measuring serum vitamin A and carotenoid levels in patients who were at risk of subsequent HIV infection. In a nested case-control study in individuals attending two sexually transmitted disease (STD) clinics in Pune, India, serum micronutrient levels were measured in 44 cases with documented HIV seroconversion (11 women and 33 men) and in STD patients matched for gender and length of follow-up with no subsequent HIV seroconversion (controls). STD patients in Pune had low vitamin A and carotenoid levels, and low serum β-carotene levels were independently associated with an increased risk of subsequent HIV seroconversion. STD patients with β-carotene levels less than 0.075 μmol/L were 21 times more likely to acquire HIV infection than those with higher levels (adjusted odds ratio = 21.1; p = .01). No such association was observed in case of other non-provitamin A carotenoids. This study reports the first evidence of an association between low serum provitamin A carotenoid levels and an increased risk for heterosexual HIV acquisition in STD patients in Pune, India.",
keywords = "Carotenoids, Seroconversion, Vitamin A",
author = "Mehendale, {Sanjay M.} and Shepherd, {Mary E.} and Brookmeyer, {Ronald S.} and Semba, {Richard David} and Divekar, {Anand D.} and Gangakhedkar, {Raman R.} and Smita Joshi and Risbud, {Arun R.} and Paranjape, {Ramesh S.} and Gadkari, {Deepak A.} and Bollinger, {Robert C}",
year = "2001",
month = "4",
day = "1",
language = "English (US)",
volume = "26",
pages = "352--359",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Low carotenoid concentration and the risk of HIV seroconversion in Pune, India

AU - Mehendale, Sanjay M.

AU - Shepherd, Mary E.

AU - Brookmeyer, Ronald S.

AU - Semba, Richard David

AU - Divekar, Anand D.

AU - Gangakhedkar, Raman R.

AU - Joshi, Smita

AU - Risbud, Arun R.

AU - Paranjape, Ramesh S.

AU - Gadkari, Deepak A.

AU - Bollinger, Robert C

PY - 2001/4/1

Y1 - 2001/4/1

N2 - Low vitamin A and carotenoid levels could increase the risk of sexual HIV acquisition by altering the integrity of the genital epithelium or by immunologic dysfunction. We addressed this issue by measuring serum vitamin A and carotenoid levels in patients who were at risk of subsequent HIV infection. In a nested case-control study in individuals attending two sexually transmitted disease (STD) clinics in Pune, India, serum micronutrient levels were measured in 44 cases with documented HIV seroconversion (11 women and 33 men) and in STD patients matched for gender and length of follow-up with no subsequent HIV seroconversion (controls). STD patients in Pune had low vitamin A and carotenoid levels, and low serum β-carotene levels were independently associated with an increased risk of subsequent HIV seroconversion. STD patients with β-carotene levels less than 0.075 μmol/L were 21 times more likely to acquire HIV infection than those with higher levels (adjusted odds ratio = 21.1; p = .01). No such association was observed in case of other non-provitamin A carotenoids. This study reports the first evidence of an association between low serum provitamin A carotenoid levels and an increased risk for heterosexual HIV acquisition in STD patients in Pune, India.

AB - Low vitamin A and carotenoid levels could increase the risk of sexual HIV acquisition by altering the integrity of the genital epithelium or by immunologic dysfunction. We addressed this issue by measuring serum vitamin A and carotenoid levels in patients who were at risk of subsequent HIV infection. In a nested case-control study in individuals attending two sexually transmitted disease (STD) clinics in Pune, India, serum micronutrient levels were measured in 44 cases with documented HIV seroconversion (11 women and 33 men) and in STD patients matched for gender and length of follow-up with no subsequent HIV seroconversion (controls). STD patients in Pune had low vitamin A and carotenoid levels, and low serum β-carotene levels were independently associated with an increased risk of subsequent HIV seroconversion. STD patients with β-carotene levels less than 0.075 μmol/L were 21 times more likely to acquire HIV infection than those with higher levels (adjusted odds ratio = 21.1; p = .01). No such association was observed in case of other non-provitamin A carotenoids. This study reports the first evidence of an association between low serum provitamin A carotenoid levels and an increased risk for heterosexual HIV acquisition in STD patients in Pune, India.

KW - Carotenoids

KW - Seroconversion

KW - Vitamin A

UR - http://www.scopus.com/inward/record.url?scp=0035309827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035309827&partnerID=8YFLogxK

M3 - Article

C2 - 11317078

AN - SCOPUS:0035309827

VL - 26

SP - 352

EP - 359

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 4

ER -