Low antibody response in infants with measles and children with subclinical measles virus infection

T. Cherian, A. Joseph, T. J. John

Research output: Contribution to journalArticlepeer-review

Abstract

During a measles epidemic (December 1979-March 1980) in two adjacent villages in Tamil Nadu, 78 of 143 under-fives were affected, eight of whom died, giving an attack rate of 54% and case-fatality rate of 10%. Seven months later 72 children (41 with measles, seven with history of measles in prior epidemics and 24 with no history of measles) were bled to measure measles virus haemagglutination-inhibition antibody. Of the 48 with measles history, 46 had measurable antibody. Surprisingly, of the 24 without a history, 16 had measurable antibody indicating the frequency of subclinical measles during epidemics. The geometric mean antibody titre was lower in infants with measles than in older children (P < 0.05). The mean titre was lower in those with subclinical measles than in those with clinical measles (P < 0.01).

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Tropical Medicine and Hygiene
Volume87
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Environmental Science(all)
  • Engineering(all)
  • Infectious Diseases
  • Earth and Planetary Sciences(all)

Fingerprint Dive into the research topics of 'Low antibody response in infants with measles and children with subclinical measles virus infection'. Together they form a unique fingerprint.

Cite this