Low antibody response in infants with measles and children with subclinical measles virus infection

Thomas Cherian, A. Joseph, T. J. John

Research output: Contribution to journalArticle

Abstract

During a measles epidemic (December 1979-March 1980) in two adjacent villages in Tamil Nadu, 78 of 143 under-fives were affected, eight of whom died, giving an attack rate of 54% and case-fatality rate of 10%. Seven months later 72 children (41 with measles, seven with history of measles in prior epidemics and 24 with no history of measles) were bled to measure measles virus haemagglutination-inhibition antibody. Of the 48 with measles history, 46 had measurable antibody. Surprisingly, of the 24 without a history, 16 had measurable antibody indicating the frequency of subclinical measles during epidemics. The geometric mean antibody titre was lower in infants with measles than in older children (P < 0.05). The mean titre was lower in those with subclinical measles than in those with clinical measles (P < 0.01).

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Tropical Medicine and Hygiene
Volume87
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

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measles
Measles virus
Measles
Virus Diseases
Viruses
Antibodies
antibody
Antibody Formation
virus
history
infection
infant
Hemagglutination
History
village

ASJC Scopus subject areas

  • Parasitology
  • Environmental Science(all)
  • Engineering(all)
  • Earth and Planetary Sciences(all)
  • Infectious Diseases

Cite this

Low antibody response in infants with measles and children with subclinical measles virus infection. / Cherian, Thomas; Joseph, A.; John, T. J.

In: Journal of Tropical Medicine and Hygiene, Vol. 87, No. 1, 01.01.1984, p. 27-31.

Research output: Contribution to journalArticle

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