TY - JOUR
T1 - Low 25-Hydroxyvitamin D Concentrations and Risk of Incident Cognitive Impairment in Black and White Older Adults
T2 - The Health ABC Study
AU - Kilpatrick, Laurel
AU - Houston, Denise K.
AU - Wilson, Valerie K.
AU - Lovato, James
AU - Ayonayon, Hilsa N.
AU - Cauley, Jane A.
AU - Harris, Tamara
AU - Simonsick, Eleanor M.
AU - Yaffe, Kristine
AU - Kritchevsky, Stephen B.
AU - Sink, Kaycee M.
N1 - Publisher Copyright:
© 2018 Taylor & Francis.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Using data from the Health, Aging, and Body Composition study, we examined whether low 25-hydroxyvitamin D (25[OH]D) concentrations were associated with prevalent or incident cognitive impairment. Serum 25(OH)D concentrations were measured in 2,786 older adults and categorized as <20 ng/mL, 20 to <30 ng/mL, or ≥30 ng/mL. Cognitive impairment was defined as a score >1.5 standard deviations below race and education specific means on either digit symbol substitution test or modified mini-mental state test. Logistic regression determined the odds of cognitive impairment at baseline and year 5 by 25(OH)D category. 25(OH)D concentrations were <30 ng/mL in 57.3% of whites and 84.6% of blacks. After excluding participants with baseline cognitive impairment (n = 340), 13% of whites and 13% of blacks developed cognitive impairment by year 5. In whites, 25(OH)D concentrations <30 ng/mL were not associated with prevalent or incident cognitive impairment. Black participants with 25(OH)D concentrations <20 ng/mL had a higher odds of prevalent, but not incident cognitive impairment (OR (95% CI): 2.05 (1.08–3.91), p = 0.03) compared to participants with 25(OH)D concentrations ≥30 ng/mL. Low 25(OH)D concentrations were associated with twofold higher odds of prevalent cognitive impairment in blacks.
AB - Using data from the Health, Aging, and Body Composition study, we examined whether low 25-hydroxyvitamin D (25[OH]D) concentrations were associated with prevalent or incident cognitive impairment. Serum 25(OH)D concentrations were measured in 2,786 older adults and categorized as <20 ng/mL, 20 to <30 ng/mL, or ≥30 ng/mL. Cognitive impairment was defined as a score >1.5 standard deviations below race and education specific means on either digit symbol substitution test or modified mini-mental state test. Logistic regression determined the odds of cognitive impairment at baseline and year 5 by 25(OH)D category. 25(OH)D concentrations were <30 ng/mL in 57.3% of whites and 84.6% of blacks. After excluding participants with baseline cognitive impairment (n = 340), 13% of whites and 13% of blacks developed cognitive impairment by year 5. In whites, 25(OH)D concentrations <30 ng/mL were not associated with prevalent or incident cognitive impairment. Black participants with 25(OH)D concentrations <20 ng/mL had a higher odds of prevalent, but not incident cognitive impairment (OR (95% CI): 2.05 (1.08–3.91), p = 0.03) compared to participants with 25(OH)D concentrations ≥30 ng/mL. Low 25(OH)D concentrations were associated with twofold higher odds of prevalent cognitive impairment in blacks.
KW - Cognitive impairment
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85042913117&partnerID=8YFLogxK
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U2 - 10.1080/21551197.2017.1419899
DO - 10.1080/21551197.2017.1419899
M3 - Article
C2 - 29505349
AN - SCOPUS:85042913117
SN - 2155-1197
VL - 37
SP - 1
EP - 13
JO - Journal of Nutrition in Gerontology and Geriatrics
JF - Journal of Nutrition in Gerontology and Geriatrics
IS - 1
ER -