Lost in Translation: Cul3-Dependent Pathological Mechanisms in Psychiatric Disorders

Huei Ying Chen, Brady J. Maher

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Neuron, Dong et al. (2020) finds that deficiency of the psychiatric risk gene Cul3, which encodes an E3 ubiquitin ligase, leads to an upregulation of Cap-dependent protein translation. The resulting imbalance in protein synthesis and degradation is found to disrupt glutamatergic transmission and excitability in networks that underlie sociability and anxiety.

Original languageEnglish (US)
Pages (from-to)398-399
Number of pages2
JournalNeuron
Volume105
Issue number3
DOIs
StatePublished - Feb 5 2020

ASJC Scopus subject areas

  • Neuroscience(all)

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