Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

Scott Kominsky, Pedram Argani, Dorian Korz, Ella Evron, Venu Raman, Elizabeth Garrett, Alan Rein, Guido Sauter, Olli P. Kallioniemi, Saraswati Sukumar

Research output: Contribution to journalArticle

Abstract

Claudins are transmembrane proteins that seal tight junctions, and are critical for maintaining cell-to-cell adhesion in epithelial cell sheets. However, their role in cancer progression remains largely unexplored. Here, we report that Claudin-7 (CLDN-7) expression is lower in invasive ductal carcinomas (IDC) of the breast than in normal breast epithelium, as determined by both RT-PCR (9/10) and Western analysis (6/8). Immunohistochemical (IHC) analysis of ductal carcinoma in situ (DCIS) and IDC showed that the loss of CLDN-7 expression correlated with histological grade in both DCIS (P

Original languageEnglish (US)
Pages (from-to)2021-2033
Number of pages13
JournalOncogene
Volume22
Issue number13
DOIs
StatePublished - Apr 3 2003

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Keywords

  • Breast cancer
  • Claudin-7
  • Methylation
  • Tight junction

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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