Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee; Jianzhou Wang; Michael Torbenson; You Lu; Qiong Z. Liu; Shibo Li

doi:10.1016/j.cancergencyto.2009.09.005

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee, Jianzhou Wang, Michael Torbenson, You Lu, Qiong Z. Liu, Shibo Li

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

Original language	English (US)
Pages (from-to)	179-183
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.09.005
State	Published - Jan 15 2010
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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abstract = "We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.",

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AU - Lu, You

AU - Liu, Qiong Z.

AU - Li, Shibo

PY - 2010/1/15

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AB - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

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Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Abstract

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