Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

Gary L. Wenk; Lary C. Walker; Donald L. Price; Linda C. Cork

doi:10.1016/0197-4580(91)90047-N

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

Gary L. Wenk, Lary C. Walker, Donald L. Price, Linda C. Cork

School of Medicine

Research output: Contribution to journal › Article › peer-review

198 Scopus citations

Abstract

In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven "young" (4-9 years), six "adult" (20-25 years), and five "aged" (29-34 years) monkeys were studied. NMDA-displaceable 1-[³H]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [³H]muscimol binding were unchanged in aged animals.

Original language	English (US)
Pages (from-to)	93-98
Number of pages	6
Journal	Neurobiology of aging
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0197-4580(91)90047-N
State	Published - 1991

Keywords

Acetylcholine
Aging
GABA
Glutamate
Monkeys
NMDA
Rats
Receptors

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(91)90047-N

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title = "Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys",

abstract = "In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven {"}young{"} (4-9 years), six {"}adult{"} (20-25 years), and five {"}aged{"} (29-34 years) monkeys were studied. NMDA-displaceable 1-[3H]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [3H]muscimol binding were unchanged in aged animals.",

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author = "Wenk, {Gary L.} and Walker, {Lary C.} and Price, {Donald L.} and Cork, {Linda C.}",

note = "Funding Information: We thank Anu Durr for typing the manuscript and Irene Malak for excellent technical assistance. This work was supported by PHS grants (NIH NS 20471 and AG 07735).",

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T1 - Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

AU - Wenk, Gary L.

AU - Walker, Lary C.

AU - Price, Donald L.

AU - Cork, Linda C.

N1 - Funding Information: We thank Anu Durr for typing the manuscript and Irene Malak for excellent technical assistance. This work was supported by PHS grants (NIH NS 20471 and AG 07735).

PY - 1991

Y1 - 1991

N2 - In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven "young" (4-9 years), six "adult" (20-25 years), and five "aged" (29-34 years) monkeys were studied. NMDA-displaceable 1-[3H]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [3H]muscimol binding were unchanged in aged animals.

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KW - Acetylcholine

KW - Aging

KW - GABA

KW - Glutamate

KW - Monkeys

KW - NMDA

KW - Rats

KW - Receptors

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JO - Neurobiology of aging

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Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

Abstract

Keywords

ASJC Scopus subject areas

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