Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

Gary L. Wenk, Lary C. Walker, Donald L. Price, Linda C. Cork

Research output: Contribution to journalArticle

Abstract

In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven "young" (4-9 years), six "adult" (20-25 years), and five "aged" (29-34 years) monkeys were studied. NMDA-displaceable 1-[3H]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [3H]muscimol binding were unchanged in aged animals.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalNeurobiology of Aging
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1991

Keywords

  • Acetylcholine
  • Aging
  • GABA
  • Glutamate
  • Monkeys
  • NMDA
  • Rats
  • Receptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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