Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, Se Jin Lee

Research output: Contribution to journalArticle

Abstract

Myostatin, a transforming growth factor-β family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalAnnals of neurology
Volume52
Issue number6
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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