Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

Kathryn R. Wagner; Alexandra C. McPherron; Nicole Winik; Se Jin Lee

doi:10.1002/ana.10385

Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, Se Jin Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

Myostatin, a transforming growth factor-β family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.

Original language	English (US)
Pages (from-to)	832-836
Number of pages	5
Journal	Annals of neurology
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/ana.10385
State	Published - Dec 1 2002

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Myostatin, a transforming growth factor-β family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.",

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Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

Abstract

ASJC Scopus subject areas

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