Loss of imprinting in hepatoblastoma

S. Rainier, C. J. Dobry, Andrew P Feinberg

Research output: Contribution to journalArticle

Abstract

We and others have described loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that LOI is a general feature of embryonal tumors is challenged by a report of absence of LOI in three hepatoblastomas (S. M. Davies, Cancer Res., 53: 47814783, 1993). We identified five hepatoblastomas informative for a transcribed polymorphism of the IGF2 gene. One tumor showed LOI of IGF2, in contrast to the previous report. That tumor also showed LOI of H19, further documenting a role for this gene in imprinting disturbances in cancer. However, in contrast to WT, LOI in hepatoblastoma was not associated with down-regulation of H19. Thus IGF2 and H19 expression can be uncoupled in tumors with LOI.

Original languageEnglish (US)
Pages (from-to)1836-1838
Number of pages3
JournalCancer Research
Volume55
Issue number9
StatePublished - 1995

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Hepatoblastoma
Wilms Tumor
Neoplasms
Genes
Down-Regulation
Embryonal Rhabdomyosarcoma
Insulin-Like Growth Factor II
Second Primary Neoplasms
Germ Cell and Embryonal Neoplasms
Kidney

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rainier, S., Dobry, C. J., & Feinberg, A. P. (1995). Loss of imprinting in hepatoblastoma. Cancer Research, 55(9), 1836-1838.

Loss of imprinting in hepatoblastoma. / Rainier, S.; Dobry, C. J.; Feinberg, Andrew P.

In: Cancer Research, Vol. 55, No. 9, 1995, p. 1836-1838.

Research output: Contribution to journalArticle

Rainier, S, Dobry, CJ & Feinberg, AP 1995, 'Loss of imprinting in hepatoblastoma', Cancer Research, vol. 55, no. 9, pp. 1836-1838.
Rainier S, Dobry CJ, Feinberg AP. Loss of imprinting in hepatoblastoma. Cancer Research. 1995;55(9):1836-1838.
Rainier, S. ; Dobry, C. J. ; Feinberg, Andrew P. / Loss of imprinting in hepatoblastoma. In: Cancer Research. 1995 ; Vol. 55, No. 9. pp. 1836-1838.
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