TY - JOUR
T1 - Loss of Imprinting in Hepatoblastoma
AU - Rainier, Shirley
AU - Dobry, Craig J.
AU - Feinberg, Andrew P.
PY - 1995/5/1
Y1 - 1995/5/1
N2 - We and others have described loss of imprinting (LOI) of the insulinlike growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that LOI is a general feature of embryonal tumors is challenged by a report of absence of LOI in three hepatoblastomas (S. M. Davies, Cancer Res., 53: 4781-4783, 1993). We identified five hepatoblastomas informative for a transcribed polymorphism of the IGF2 gene. One tumor showed LOI of IGF2, in contrast to the previous report That tumor also showed LOI of H19, further documenting a role for this gene in imprinting disturbances in cancer. However, in contrast to WT, LOI in hepatoblastoma was not associated with down-regulation of H19. Thus, IGF2 and H19 expression can be uncoupled in tumors with LOI.
AB - We and others have described loss of imprinting (LOI) of the insulinlike growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that LOI is a general feature of embryonal tumors is challenged by a report of absence of LOI in three hepatoblastomas (S. M. Davies, Cancer Res., 53: 4781-4783, 1993). We identified five hepatoblastomas informative for a transcribed polymorphism of the IGF2 gene. One tumor showed LOI of IGF2, in contrast to the previous report That tumor also showed LOI of H19, further documenting a role for this gene in imprinting disturbances in cancer. However, in contrast to WT, LOI in hepatoblastoma was not associated with down-regulation of H19. Thus, IGF2 and H19 expression can be uncoupled in tumors with LOI.
UR - http://www.scopus.com/inward/record.url?scp=0028920031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028920031&partnerID=8YFLogxK
M3 - Article
C2 - 7728748
AN - SCOPUS:0028920031
SN - 0008-5472
VL - 55
SP - 1836
EP - 1838
JO - Cancer Research
JF - Cancer Research
IS - 9
ER -