Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice

Lori L. Hampton, Ellen Elizabeth Ladenheim, Mark Akeson, James M. Way, H. Christian Weber, Vince E. Sutliff, Robert T. Jensen, Lara J. Wine, Heinz Arnheiter, James F. Battey

Research output: Contribution to journalArticle

Abstract

The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.

Original languageEnglish (US)
Pages (from-to)3188-3192
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number6
DOIs
StatePublished - Mar 17 1998

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Bombesin Receptors
Bombesin
Genes
Glucose
Neurosecretory Systems
X Chromosome
Chemotaxis
Embryonic Development
Growth

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. / Hampton, Lori L.; Ladenheim, Ellen Elizabeth; Akeson, Mark; Way, James M.; Weber, H. Christian; Sutliff, Vince E.; Jensen, Robert T.; Wine, Lara J.; Arnheiter, Heinz; Battey, James F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 6, 17.03.1998, p. 3188-3192.

Research output: Contribution to journalArticle

Hampton, Lori L. ; Ladenheim, Ellen Elizabeth ; Akeson, Mark ; Way, James M. ; Weber, H. Christian ; Sutliff, Vince E. ; Jensen, Robert T. ; Wine, Lara J. ; Arnheiter, Heinz ; Battey, James F. / Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 6. pp. 3188-3192.
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