Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice

Lori L. Hampton, Ellen Elizabeth Ladenheim, Mark Akeson, James M. Way, H. Christian Weber, Vince E. Sutliff, Robert T. Jensen, Lara J. Wine, Heinz Arnheiter, James F. Battey

Research output: Contribution to journalArticle

Abstract

The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.

Original languageEnglish (US)
Pages (from-to)3188-3192
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number6
DOIs
Publication statusPublished - Mar 17 1998

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ASJC Scopus subject areas

  • Genetics
  • General

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