Losing balance: The origin and impact of aneuploidy in cancer

Andrew J. Holland, Don W. Cleveland

Research output: Contribution to journalReview articlepeer-review

Abstract

Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.

Original languageEnglish (US)
Pages (from-to)501-514
Number of pages14
JournalEMBO Reports
Volume13
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • aneuploidy
  • cancer
  • centrosome
  • mitosis
  • tumour

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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