Losartan improves measures of activity, inflammation, and oxidative stress in older mice

Chung Hao Lin, Huanle Yang, Qian Li Xue, Yi Fang Chuang, Cindy N. Roy, Peter Abadir, Jeremy D Walston

Research output: Contribution to journalArticle

Abstract

Sarcopenia is an age-related decline in skeletal muscle mass and function that is multifactorial in etiology. Age-related changes in the renin-angiotensin system (RAS), increased oxidative stress, and chronic inflammation likely all contribute to its development. Losartan, an angiotensin II type I receptor blocker (ARB) decreases RAS activity and likely influences oxidative stress and inflammation. Given this, we hypothesized that losartan would improve activity levels and parameters related to inflammation and oxidative stress in older mice. We sought to test this hypothesis by comparing functional and molecular parameters between 18-month-old C57BL/6 mice treated with 50-70. mg/kg/day of losartan over a 4. month-period and age- and gender-matched mice receiving placebo. Losartan treatment significantly improved several activity measurements during treatment period compared to placebo controlled group, including increased time on treadmill, traveling activity, standing activity, and decreased grid contacts (p-values.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalExperimental Gerontology
Volume58
DOIs
StatePublished - 2014

Fingerprint

Oxidative stress
Losartan
Oxidative Stress
Inflammation
Angiotensins
Renin-Angiotensin System
Renin
Placebos
Sarcopenia
Angiotensin I
Exercise equipment
Angiotensin Receptor Antagonists
Inbred C57BL Mouse
Angiotensin II
Muscle
Skeletal Muscle
Therapeutics

Keywords

  • Angiotensin II receptor blocker
  • Frailty
  • Inflammation
  • Oxidative stress
  • Renin-angiotensin system
  • Sarcopenia

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Losartan improves measures of activity, inflammation, and oxidative stress in older mice. / Lin, Chung Hao; Yang, Huanle; Xue, Qian Li; Chuang, Yi Fang; Roy, Cindy N.; Abadir, Peter; Walston, Jeremy D.

In: Experimental Gerontology, Vol. 58, 2014, p. 174-178.

Research output: Contribution to journalArticle

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AU - Abadir, Peter

AU - Walston, Jeremy D

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