Lorenzo's Oil and Thrombocytopenia in Patients with Adrenoleukodystrophy

William H. Zinkham, Thomas Kickler, Janet Borel, Hugo W. Moser

Research output: Contribution to journalLetter

Abstract

To the Editor: Adrenoleukodystrophy is a sex-linked disorder in which very-long-chain fatty acids accumulate in all body tissues1. For this reason, a variety of diets have been formulated to lower the levels of these acids. One diet includes Lorenzo's Oil, a product that contains 20 percent erucic acid (22:1) and 80 percent oleic acid (18:1). During the past two years, 40 male and 6 female patients have received Lorenzo's Oil according to a protocol calculated to provide 20 percent of daily caloric intake. In 19 of these patients the platelet count has decreased significantly (Table 1). The degree of…

Original languageEnglish (US)
Pages (from-to)1126-1127
Number of pages2
JournalNew England Journal of Medicine
Volume328
Issue number15
DOIs
StatePublished - Apr 15 1993

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ASJC Scopus subject areas

  • Medicine(all)

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