Long‐term potentiation in the avian hippocampus does not require activation of the N‐methyl‐D‐aspartate (NMDA) receptor

Andrzej Wieraszko, Gregory F. Ball

Research output: Contribution to journalArticlepeer-review

Abstract

Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 × 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK‐801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long‐term potentiation, does not depend on the activation of NMDA receptors. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalSynapse
Volume13
Issue number2
DOIs
StatePublished - Feb 1993

Keywords

  • APV
  • Evoked potential
  • Kynurenic acid
  • MK 801
  • Pigeon

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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