Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy

Qianqian Zhao, Paul J. Rathouz, Jana E. Jones, Daren C. Jackson, David A. Hsu, Carl Stafstrom, Michael Seidenberg, Bruce P. Hermann

Research output: Contribution to journalArticle

Abstract

Aim: To characterize the prospective trajectory of parent-reported behavior and social competence problems in children with new or recent onset epilepsy from diagnosis to 5 to 6 years after diagnosis compared to healthy control participants. Method: Thirty-five children (21 males, 14 females; mean age 14y 1mo [SD 3y 4mo] range 8-18y) with new/recent onset idiopathic generalized (IGE) and 34 children with localization-related epilepsies (LRE; 19 males, 15 females; mean age 10y 8mo [SD 2y 2mo] range 8-18y) underwent behavioral assessment (Child Behavior Checklist) at baseline, 2 years, and 5 to 6 years after diagnosis. The assessment comprised the summary scales Total Behavior Problems Internalizing Problems, Externalizing Problems, and Total Competence. Sixty-two children with normal development served as comparison participants. Analyses were based on random effects regression modeling comparing trajectories with respect to time since epilepsy diagnosis among groups. Results: Differences in parent-reported behavioral problems between LRE and IGE syndrome groups and healthy comparison participants were detectable at or near the time of diagnosis and remained either stable (competence) or tended to abate (behavior problems) over the ensuing 5 to 6 years without evidence of progressive worsening. These trends were evident for both LRE and IGE groups, with no differences between them. Interpretation: Behavior and competence problems in children with LRE and IGE are not characterized by progressive worsening over a 5- to 6-year period. Behavioral problems are present near the time of diagnosis and tend to abate over time, with competence problems being more persistent across serial assessments, and present in both LRE and IGE groups.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Volume57
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Epilepsy
Mental Competency
Healthy Volunteers
Partial Epilepsy
Social Problems
Child Behavior
Checklist
Social Skills
Problem Behavior

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience

Cite this

Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy. / Zhao, Qianqian; Rathouz, Paul J.; Jones, Jana E.; Jackson, Daren C.; Hsu, David A.; Stafstrom, Carl; Seidenberg, Michael; Hermann, Bruce P.

In: Developmental Medicine and Child Neurology, Vol. 57, No. 1, 01.01.2015, p. 37-44.

Research output: Contribution to journalArticle

Zhao, Qianqian ; Rathouz, Paul J. ; Jones, Jana E. ; Jackson, Daren C. ; Hsu, David A. ; Stafstrom, Carl ; Seidenberg, Michael ; Hermann, Bruce P. / Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy. In: Developmental Medicine and Child Neurology. 2015 ; Vol. 57, No. 1. pp. 37-44.
@article{1e247a98b81a4ca5a486daeec1531702,
title = "Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy",
abstract = "Aim: To characterize the prospective trajectory of parent-reported behavior and social competence problems in children with new or recent onset epilepsy from diagnosis to 5 to 6 years after diagnosis compared to healthy control participants. Method: Thirty-five children (21 males, 14 females; mean age 14y 1mo [SD 3y 4mo] range 8-18y) with new/recent onset idiopathic generalized (IGE) and 34 children with localization-related epilepsies (LRE; 19 males, 15 females; mean age 10y 8mo [SD 2y 2mo] range 8-18y) underwent behavioral assessment (Child Behavior Checklist) at baseline, 2 years, and 5 to 6 years after diagnosis. The assessment comprised the summary scales Total Behavior Problems Internalizing Problems, Externalizing Problems, and Total Competence. Sixty-two children with normal development served as comparison participants. Analyses were based on random effects regression modeling comparing trajectories with respect to time since epilepsy diagnosis among groups. Results: Differences in parent-reported behavioral problems between LRE and IGE syndrome groups and healthy comparison participants were detectable at or near the time of diagnosis and remained either stable (competence) or tended to abate (behavior problems) over the ensuing 5 to 6 years without evidence of progressive worsening. These trends were evident for both LRE and IGE groups, with no differences between them. Interpretation: Behavior and competence problems in children with LRE and IGE are not characterized by progressive worsening over a 5- to 6-year period. Behavioral problems are present near the time of diagnosis and tend to abate over time, with competence problems being more persistent across serial assessments, and present in both LRE and IGE groups.",
author = "Qianqian Zhao and Rathouz, {Paul J.} and Jones, {Jana E.} and Jackson, {Daren C.} and Hsu, {David A.} and Carl Stafstrom and Michael Seidenberg and Hermann, {Bruce P.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/dmcn.12549",
language = "English (US)",
volume = "57",
pages = "37--44",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Longitudinal trajectories of behavior problems and social competence in children with new onset epilepsy

AU - Zhao, Qianqian

AU - Rathouz, Paul J.

AU - Jones, Jana E.

AU - Jackson, Daren C.

AU - Hsu, David A.

AU - Stafstrom, Carl

AU - Seidenberg, Michael

AU - Hermann, Bruce P.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Aim: To characterize the prospective trajectory of parent-reported behavior and social competence problems in children with new or recent onset epilepsy from diagnosis to 5 to 6 years after diagnosis compared to healthy control participants. Method: Thirty-five children (21 males, 14 females; mean age 14y 1mo [SD 3y 4mo] range 8-18y) with new/recent onset idiopathic generalized (IGE) and 34 children with localization-related epilepsies (LRE; 19 males, 15 females; mean age 10y 8mo [SD 2y 2mo] range 8-18y) underwent behavioral assessment (Child Behavior Checklist) at baseline, 2 years, and 5 to 6 years after diagnosis. The assessment comprised the summary scales Total Behavior Problems Internalizing Problems, Externalizing Problems, and Total Competence. Sixty-two children with normal development served as comparison participants. Analyses were based on random effects regression modeling comparing trajectories with respect to time since epilepsy diagnosis among groups. Results: Differences in parent-reported behavioral problems between LRE and IGE syndrome groups and healthy comparison participants were detectable at or near the time of diagnosis and remained either stable (competence) or tended to abate (behavior problems) over the ensuing 5 to 6 years without evidence of progressive worsening. These trends were evident for both LRE and IGE groups, with no differences between them. Interpretation: Behavior and competence problems in children with LRE and IGE are not characterized by progressive worsening over a 5- to 6-year period. Behavioral problems are present near the time of diagnosis and tend to abate over time, with competence problems being more persistent across serial assessments, and present in both LRE and IGE groups.

AB - Aim: To characterize the prospective trajectory of parent-reported behavior and social competence problems in children with new or recent onset epilepsy from diagnosis to 5 to 6 years after diagnosis compared to healthy control participants. Method: Thirty-five children (21 males, 14 females; mean age 14y 1mo [SD 3y 4mo] range 8-18y) with new/recent onset idiopathic generalized (IGE) and 34 children with localization-related epilepsies (LRE; 19 males, 15 females; mean age 10y 8mo [SD 2y 2mo] range 8-18y) underwent behavioral assessment (Child Behavior Checklist) at baseline, 2 years, and 5 to 6 years after diagnosis. The assessment comprised the summary scales Total Behavior Problems Internalizing Problems, Externalizing Problems, and Total Competence. Sixty-two children with normal development served as comparison participants. Analyses were based on random effects regression modeling comparing trajectories with respect to time since epilepsy diagnosis among groups. Results: Differences in parent-reported behavioral problems between LRE and IGE syndrome groups and healthy comparison participants were detectable at or near the time of diagnosis and remained either stable (competence) or tended to abate (behavior problems) over the ensuing 5 to 6 years without evidence of progressive worsening. These trends were evident for both LRE and IGE groups, with no differences between them. Interpretation: Behavior and competence problems in children with LRE and IGE are not characterized by progressive worsening over a 5- to 6-year period. Behavioral problems are present near the time of diagnosis and tend to abate over time, with competence problems being more persistent across serial assessments, and present in both LRE and IGE groups.

UR - http://www.scopus.com/inward/record.url?scp=84916633190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916633190&partnerID=8YFLogxK

U2 - 10.1111/dmcn.12549

DO - 10.1111/dmcn.12549

M3 - Article

C2 - 25040537

AN - SCOPUS:84916633190

VL - 57

SP - 37

EP - 44

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

IS - 1

ER -