Longitudinal systolic left ventricular function in preterm and term neonates: Reference values of the mitral annular plane systolic excursion (MAPSE) and calculation of z-scores

Martin Koestenberger, Bert Nagel, William Ravekes, Andreas Gamillscheg, Corinna Binder, Alexander Avian, Jasmin Pansy, Gerhard Cvirn, Berndt Urlesberger

Research output: Contribution to journalArticle

Abstract

The mitral annular plane systolic excursion (MAPSE) is a quick and reliable echocardiographic tool for assessing longitudinal left ventricular (LV) systolic function in children and adults. Because this parameter is affected by the LV longitudinal dimension, pediatric and adult normal values are not suitable for preterm and term neonates. A prospective study investigated a large group of preterm and term neonates [gestational age (GA), 26/0–6 to 40/0–6; birth weight (BW), 670–4,140 g]. The growth- and BW-related changes in MAPSE were determined to establish normal z-score values for preterm and term neonates. The MAPSE ranged from a mean of 0.36 ± 0.05 cm in preterm neonates with a GA of 26/0–6 to 0.56 ± 0.08 cm in term neonates with a GA of 40/0–6. The findings showed MAPSE, GA, and BW to be moderately correlated. Pearson’s correlation coefficient was 0.56 for GA (MAPSE; p <0.001) and 0.58 for BW (MAPSE; p <0.001). The normal MAPSE values did not differ significantly between females and males (p = 0.946). The absolute values and z-scores of normal MAPSE values in healthy preterm and term neonates within the first 48 h of life were calculated, and percentile charts were established. Determination of LV function using MAPSE might be useful for vulnerable infants for whom a prolonged examination is inappropriate and for neonates with sub-optimal visualization of the endocardium.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalPediatric Cardiology
Volume36
Issue number1
DOIs
StatePublished - Jul 31 2015

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Left Ventricular Function
Reference Values
Newborn Infant
Gestational Age
Birth Weight
Endocardium
Prospective Studies
Pediatrics
Growth

Keywords

  • Birth weight
  • Left ventricular long-axis function
  • M-mode
  • Mitral annular plane systolic excursion
  • Neonates
  • Preterm
  • Reference values
  • z-Score

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Longitudinal systolic left ventricular function in preterm and term neonates : Reference values of the mitral annular plane systolic excursion (MAPSE) and calculation of z-scores. / Koestenberger, Martin; Nagel, Bert; Ravekes, William; Gamillscheg, Andreas; Binder, Corinna; Avian, Alexander; Pansy, Jasmin; Cvirn, Gerhard; Urlesberger, Berndt.

In: Pediatric Cardiology, Vol. 36, No. 1, 31.07.2015, p. 20-26.

Research output: Contribution to journalArticle

Koestenberger, Martin ; Nagel, Bert ; Ravekes, William ; Gamillscheg, Andreas ; Binder, Corinna ; Avian, Alexander ; Pansy, Jasmin ; Cvirn, Gerhard ; Urlesberger, Berndt. / Longitudinal systolic left ventricular function in preterm and term neonates : Reference values of the mitral annular plane systolic excursion (MAPSE) and calculation of z-scores. In: Pediatric Cardiology. 2015 ; Vol. 36, No. 1. pp. 20-26.
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AU - Gamillscheg, Andreas

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AU - Pansy, Jasmin

AU - Cvirn, Gerhard

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AB - The mitral annular plane systolic excursion (MAPSE) is a quick and reliable echocardiographic tool for assessing longitudinal left ventricular (LV) systolic function in children and adults. Because this parameter is affected by the LV longitudinal dimension, pediatric and adult normal values are not suitable for preterm and term neonates. A prospective study investigated a large group of preterm and term neonates [gestational age (GA), 26/0–6 to 40/0–6; birth weight (BW), 670–4,140 g]. The growth- and BW-related changes in MAPSE were determined to establish normal z-score values for preterm and term neonates. The MAPSE ranged from a mean of 0.36 ± 0.05 cm in preterm neonates with a GA of 26/0–6 to 0.56 ± 0.08 cm in term neonates with a GA of 40/0–6. The findings showed MAPSE, GA, and BW to be moderately correlated. Pearson’s correlation coefficient was 0.56 for GA (MAPSE; p <0.001) and 0.58 for BW (MAPSE; p <0.001). The normal MAPSE values did not differ significantly between females and males (p = 0.946). The absolute values and z-scores of normal MAPSE values in healthy preterm and term neonates within the first 48 h of life were calculated, and percentile charts were established. Determination of LV function using MAPSE might be useful for vulnerable infants for whom a prolonged examination is inappropriate and for neonates with sub-optimal visualization of the endocardium.

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