Longitudinal study of quality of life in people with advanced Alzheimer's disease

Steven M. Albert, Diane M. Jacobs, Mary Sano, Karen Marder, Karen Bell, Davangere Devanand, Jason Brandt, Marilyn Albert, Yaakov Stern

Research output: Contribution to journalArticlepeer-review

Abstract

The authors examined three indicators of health-related quality of life in people with advanced Alzheimer's disease ([AD]; N = 150): confinement to home, null activity, and null positive affect, as reported by patient proxies. Dementia severity predicted time-to-onset for all three disease milestones in models that controlled for sociodemographic indicators, nursing home status, and death in the follow-up period. Patients whose dementia worsened over follow-up were more likely to reach each milestone. These outcomes represent key milestones in the care of patients; they are sensitive to disease progression, and they are likely to be useful for studying treatment in advanced AD.

Original languageEnglish (US)
Pages (from-to)160-168
Number of pages9
JournalAmerican Journal of Geriatric Psychiatry
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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