TY - JOUR
T1 - Longitudinal study of quality of life in people with advanced Alzheimer's disease
AU - Albert, Steven M.
AU - Jacobs, Diane M.
AU - Sano, Mary
AU - Marder, Karen
AU - Bell, Karen
AU - Devanand, Davangere
AU - Brandt, Jason
AU - Albert, Marilyn
AU - Stern, Yaakov
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The authors examined three indicators of health-related quality of life in people with advanced Alzheimer's disease ([AD]; N = 150): confinement to home, null activity, and null positive affect, as reported by patient proxies. Dementia severity predicted time-to-onset for all three disease milestones in models that controlled for sociodemographic indicators, nursing home status, and death in the follow-up period. Patients whose dementia worsened over follow-up were more likely to reach each milestone. These outcomes represent key milestones in the care of patients; they are sensitive to disease progression, and they are likely to be useful for studying treatment in advanced AD.
AB - The authors examined three indicators of health-related quality of life in people with advanced Alzheimer's disease ([AD]; N = 150): confinement to home, null activity, and null positive affect, as reported by patient proxies. Dementia severity predicted time-to-onset for all three disease milestones in models that controlled for sociodemographic indicators, nursing home status, and death in the follow-up period. Patients whose dementia worsened over follow-up were more likely to reach each milestone. These outcomes represent key milestones in the care of patients; they are sensitive to disease progression, and they are likely to be useful for studying treatment in advanced AD.
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U2 - 10.1097/00019442-200105000-00008
DO - 10.1097/00019442-200105000-00008
M3 - Article
C2 - 11316620
AN - SCOPUS:0035048718
VL - 9
SP - 160
EP - 168
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 2
ER -