Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study

John G. Palenicek, Robin Fox, Joseph Bernard Margolick, Homayoon Farzadegan, Don Hoover, Nancy Odaka, Susan Rubb, Haroutune Armenian, Jeanette Harris, Alfred J. Saah

Research output: Contribution to journalArticle

Abstract

Thirty-six sexually active couples serologically discordant for human immunodeficiency virus, type 1 (HIV-1), within the Baltimore Multicenter AIDS Cohort Study (MACS) were assessed to determine whether evidence of HIV-1 infection could be detected in the HIV-1-antibody-negative partners and whether factors associated with lack of transmission of HIV from the seropositive to the seronegative partner could be ascertained. Six HIV-1 seropositive couples and 18 seronegative couples were followed concurrently for comparison. None of the seropositive subjects had an AIDS-defining illness at entry into the study, and all subjects were followed for 1 year. A separate evaluation of unprotected anal receptive and insertive intercourse between discordant couples indicated high-risk activities for a median of 40 months, as reported by the HIV seropositive partner. Despite this finding, none of the HIV-1 seronegative men in discordant couples had evidence of HIV-1 infection by viral culture, p24 antigen testing, or polymerase chain reaction for HIV-1 DNA. Discordant seronegatives and seropositives did not differ from concordant seronegatives and seropositives in numbers of circulating CD4, CD8, and natural killer lymphocytes or in prevalence of antibodies to herpes simplex virus, type 1, Epstein-Barr virus, or cytomegalovirus, except that discordant seronegative men were less likely than their seropositive partners to have antibodies to herpes simplex virus, type 2. The reason for the apparent lack of HIV-1 infection in seronegative discordant individuals remains unexplained and did not appear to be associated with type of sexual activity, T-lymphocyte subsets or natural killer cells, or early stage of HIV-1 disease.

Original languageEnglish (US)
Pages (from-to)1204-1211
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number12
StatePublished - 1992

Fingerprint

Baltimore
Longitudinal Studies
HIV-1
Acquired Immunodeficiency Syndrome
Cohort Studies
Antibodies
Virus Diseases
HIV
Sexual Minorities
Human Herpesvirus 2
Human Herpesvirus 1
T-Lymphocyte Subsets
Cytomegalovirus
Human Herpesvirus 4
Natural Killer Cells
Sexual Behavior
Lymphocytes
Antigens
Polymerase Chain Reaction
DNA

Keywords

  • HIV-1 immunology
  • HIV-1 transmission
  • Sexual activity

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology and Allergy

Cite this

Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study. / Palenicek, John G.; Fox, Robin; Margolick, Joseph Bernard; Farzadegan, Homayoon; Hoover, Don; Odaka, Nancy; Rubb, Susan; Armenian, Haroutune; Harris, Jeanette; Saah, Alfred J.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 5, No. 12, 1992, p. 1204-1211.

Research output: Contribution to journalArticle

Palenicek, JG, Fox, R, Margolick, JB, Farzadegan, H, Hoover, D, Odaka, N, Rubb, S, Armenian, H, Harris, J & Saah, AJ 1992, 'Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study', Journal of Acquired Immune Deficiency Syndromes, vol. 5, no. 12, pp. 1204-1211.
Palenicek, John G. ; Fox, Robin ; Margolick, Joseph Bernard ; Farzadegan, Homayoon ; Hoover, Don ; Odaka, Nancy ; Rubb, Susan ; Armenian, Haroutune ; Harris, Jeanette ; Saah, Alfred J. / Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study. In: Journal of Acquired Immune Deficiency Syndromes. 1992 ; Vol. 5, No. 12. pp. 1204-1211.
@article{0153c01415dc4cd7b1af27ab3cc064b4,
title = "Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study",
abstract = "Thirty-six sexually active couples serologically discordant for human immunodeficiency virus, type 1 (HIV-1), within the Baltimore Multicenter AIDS Cohort Study (MACS) were assessed to determine whether evidence of HIV-1 infection could be detected in the HIV-1-antibody-negative partners and whether factors associated with lack of transmission of HIV from the seropositive to the seronegative partner could be ascertained. Six HIV-1 seropositive couples and 18 seronegative couples were followed concurrently for comparison. None of the seropositive subjects had an AIDS-defining illness at entry into the study, and all subjects were followed for 1 year. A separate evaluation of unprotected anal receptive and insertive intercourse between discordant couples indicated high-risk activities for a median of 40 months, as reported by the HIV seropositive partner. Despite this finding, none of the HIV-1 seronegative men in discordant couples had evidence of HIV-1 infection by viral culture, p24 antigen testing, or polymerase chain reaction for HIV-1 DNA. Discordant seronegatives and seropositives did not differ from concordant seronegatives and seropositives in numbers of circulating CD4, CD8, and natural killer lymphocytes or in prevalence of antibodies to herpes simplex virus, type 1, Epstein-Barr virus, or cytomegalovirus, except that discordant seronegative men were less likely than their seropositive partners to have antibodies to herpes simplex virus, type 2. The reason for the apparent lack of HIV-1 infection in seronegative discordant individuals remains unexplained and did not appear to be associated with type of sexual activity, T-lymphocyte subsets or natural killer cells, or early stage of HIV-1 disease.",
keywords = "HIV-1 immunology, HIV-1 transmission, Sexual activity",
author = "Palenicek, {John G.} and Robin Fox and Margolick, {Joseph Bernard} and Homayoon Farzadegan and Don Hoover and Nancy Odaka and Susan Rubb and Haroutune Armenian and Jeanette Harris and Saah, {Alfred J.}",
year = "1992",
language = "English (US)",
volume = "5",
pages = "1204--1211",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Longitudinal study of homosexual couples discordant for HIV-1 antibodies in the baltimore MACS study

AU - Palenicek, John G.

AU - Fox, Robin

AU - Margolick, Joseph Bernard

AU - Farzadegan, Homayoon

AU - Hoover, Don

AU - Odaka, Nancy

AU - Rubb, Susan

AU - Armenian, Haroutune

AU - Harris, Jeanette

AU - Saah, Alfred J.

PY - 1992

Y1 - 1992

N2 - Thirty-six sexually active couples serologically discordant for human immunodeficiency virus, type 1 (HIV-1), within the Baltimore Multicenter AIDS Cohort Study (MACS) were assessed to determine whether evidence of HIV-1 infection could be detected in the HIV-1-antibody-negative partners and whether factors associated with lack of transmission of HIV from the seropositive to the seronegative partner could be ascertained. Six HIV-1 seropositive couples and 18 seronegative couples were followed concurrently for comparison. None of the seropositive subjects had an AIDS-defining illness at entry into the study, and all subjects were followed for 1 year. A separate evaluation of unprotected anal receptive and insertive intercourse between discordant couples indicated high-risk activities for a median of 40 months, as reported by the HIV seropositive partner. Despite this finding, none of the HIV-1 seronegative men in discordant couples had evidence of HIV-1 infection by viral culture, p24 antigen testing, or polymerase chain reaction for HIV-1 DNA. Discordant seronegatives and seropositives did not differ from concordant seronegatives and seropositives in numbers of circulating CD4, CD8, and natural killer lymphocytes or in prevalence of antibodies to herpes simplex virus, type 1, Epstein-Barr virus, or cytomegalovirus, except that discordant seronegative men were less likely than their seropositive partners to have antibodies to herpes simplex virus, type 2. The reason for the apparent lack of HIV-1 infection in seronegative discordant individuals remains unexplained and did not appear to be associated with type of sexual activity, T-lymphocyte subsets or natural killer cells, or early stage of HIV-1 disease.

AB - Thirty-six sexually active couples serologically discordant for human immunodeficiency virus, type 1 (HIV-1), within the Baltimore Multicenter AIDS Cohort Study (MACS) were assessed to determine whether evidence of HIV-1 infection could be detected in the HIV-1-antibody-negative partners and whether factors associated with lack of transmission of HIV from the seropositive to the seronegative partner could be ascertained. Six HIV-1 seropositive couples and 18 seronegative couples were followed concurrently for comparison. None of the seropositive subjects had an AIDS-defining illness at entry into the study, and all subjects were followed for 1 year. A separate evaluation of unprotected anal receptive and insertive intercourse between discordant couples indicated high-risk activities for a median of 40 months, as reported by the HIV seropositive partner. Despite this finding, none of the HIV-1 seronegative men in discordant couples had evidence of HIV-1 infection by viral culture, p24 antigen testing, or polymerase chain reaction for HIV-1 DNA. Discordant seronegatives and seropositives did not differ from concordant seronegatives and seropositives in numbers of circulating CD4, CD8, and natural killer lymphocytes or in prevalence of antibodies to herpes simplex virus, type 1, Epstein-Barr virus, or cytomegalovirus, except that discordant seronegative men were less likely than their seropositive partners to have antibodies to herpes simplex virus, type 2. The reason for the apparent lack of HIV-1 infection in seronegative discordant individuals remains unexplained and did not appear to be associated with type of sexual activity, T-lymphocyte subsets or natural killer cells, or early stage of HIV-1 disease.

KW - HIV-1 immunology

KW - HIV-1 transmission

KW - Sexual activity

UR - http://www.scopus.com/inward/record.url?scp=0027056083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027056083&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 1204

EP - 1211

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 12

ER -